Recent advances in the applications of iPSC technology

Current Opinion in Biotechnology
Connor Wiegand, Ipsita Banerjee

Abstract

Pluripotent stems cells (PSCs) can be expanded indefinitely and differentiated into almost any organ-specific cell type. This has enabled the generation of disease relevant tissues from patients in scalable quantities. iPSC-derived organs and organoids are currently being evaluated both in regenerative therapy which are proceeding towards clinical trials, and for disease modeling, which are facilitating drug screening efforts for discovery of novel therapeutics. Here we will review the current efforts and advances in iPSC technology and its subsequent applications and provide a brief commentary on future outlook of this promising technology.

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Bénédicte Allam-NdoulAlain Veilleux
Nov 21, 2019·International Journal of Molecular Sciences·Elvira Immacolata ParrottaGiovanni Cuda
Dec 17, 2020·Bioengineering·Panagiotis MallisEfstathios Michalopoulos
Feb 24, 2021·Disease Models & Mechanisms·Grant F MarshallCatherine M Abbott
Apr 19, 2020·Seminars in Nephrology·Aneta PrzepiorskiAlan J Davidson

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