PMID: 6313443Jan 1, 1983

Recent advances in the biochemistry and physiology of the insulin-like growth factor/somatomedin family

The International Journal of Biochemistry
A C HeringtonA D Kuffer

Abstract

The insulin-like growth factors (IGF) or somatomedins (Sm) are a family of low molecular weight circulating growth factors which have a major, but not absolute, dependence on GH, and have been shown to stimulate body growth and skeletal metabolism in vivo. They are thus considered to mediate the effects of GH on skeletal growth. In humans, the family consists of two well-characterized forms--IGF-I or SmC (a basic peptide) and IGF-II (a "neutral" peptide)--as well as perhaps two less well characterized forms--SmA (a neutral peptide) and an acidic insulin-like activity (ILA pI 4.8). Similar IGF/Sm species have been found and well-characterized in rat serum. Some higher mol wt forms also exist in tissues and body fluids and may represent possible precursor forms. On the basis of in vitro, clinical and in vivo evidence it has been postulated that IGF-I is the primary growth factor in the adult, whilst IGF-II is probably a major foetal growth factor. In vitro the IGF/Sms have a variety of effects including (1) acute insulin-like metabolic actions, which are observed primarily in insulin target tissues and are initiated largely at insulin receptors, and (2) longer term effects, associated with cell growth and skeletal tissue metaboli...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·R M Bala, B Bhaumick
Nov 1, 1979·Molecular and Cellular Endocrinology·R C FranklinA C Herington
Feb 1, 1979·The Journal of Clinical Endocrinology and Metabolism·K HallL Fryklund
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C D StilesW J Pledger
Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·B I PosnerS Goldstein
May 15, 1978·FEBS Letters·E Rinderknecht, R Humbel
Jan 1, 1975·Annual Review of Physiology·W H DaughadayL S Phillips
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·U KaufmannE R Froesch
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R H ChochinovW H Daughaday
Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
Nov 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R C FranklinD P Cameron
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·P D Gluckman, M W Brinsmead
May 8, 1975·Nature·M J Francis, D J Hill
Oct 1, 1975·Endocrinology·L S PhillipsW H Daughaday
Dec 1, 1975·The Journal of Clinical Investigation·P L Poffenbarger
May 1, 1992·Experimental Lung Research·M H KhadempourW M Thurlbeck
Apr 1, 1972·Endocrinology·J T GarlandW H Daughaday
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R N MarshallJ J Van Wyk
Sep 1, 1974·The Journal of Clinical Endocrinology and Metabolism·M M RechlerC A Wells
Dec 1, 1974·Endocrinology·G S Eisenbarth, H E Lebovitz
Dec 11, 1974·Biochemical and Biophysical Research Communications·L FryklundH Sievertsson
Jan 14, 1972·Nature·W H DaughadayJ J Van Wyk
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·F M KennyH G Friesen
Mar 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J J Van WykR P Weaver
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·D J KnauerG L Smith
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R L Hintz, E Rinderknecht
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R L Hintz, F Liu
Jul 1, 1982·Diabetes·A M AcquavivaM M Rechler
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·A C HeringtonH G Burger
Jan 1, 1980·Endocrine Reviews·H G Friesen
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·M M RechlerR M White
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B BhaumickM D Hollenberg
Jan 1, 1981·The Journal of Clinical Investigation·D R ClemmonsJ J Van Wyk
Jan 1, 1983·The International Journal of Biochemistry·H J Cornell, A C Herington
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y KatoF Suzuki
Feb 21, 1980·The New England Journal of Medicine·L S Phillips, R Vassilopoulou-Sellin
Aug 1, 1981·The Journal of Clinical Endocrinology and Metabolism·W H DaughadayB Trivedi
Oct 22, 1981·The New England Journal of Medicine·T J MerimeeE R Froesch
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·G A WertherA C Herington
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R C BaxterR L Raison
Feb 1, 1982·Endocrinology·R Vassilopoulou-Sellin, L S Phillips
Mar 1, 1982·Endocrinology·J S RubinR A Bradshaw
Nov 1, 1981·The Journal of Clinical Endocrinology and Metabolism·L D StonesiferP O Kohler
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R W Furlanetto
Nov 1, 1981·Metabolism: Clinical and Experimental·L S Phillips, J D Kopple
Mar 15, 1980·Developmental Biology·A J D'ErcoleL E Underwood
Jul 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R W Furlanetto

Citations

Dec 1, 1984·Calcified Tissue International·E H ReddW S Jee
Jan 1, 1985·The International Journal of Biochemistry·H J CornellA C Herington
Nov 1, 1991·Journal of the Neurological Sciences·M Ullman, A Oldfors
Jul 1, 1990·Domestic Animal Endocrinology·D G ArmstrongC Goddard
Jan 1, 1990·Progress in Growth Factor Research·E J van Zoelen
Nov 1, 1996·Domestic Animal Endocrinology·P A SchoknechtA W Bell
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N L SchlechterC S Nicoll
Apr 25, 1985·Nucleic Acids Research·B S Sproat, M J Gait
Jun 1, 1986·The Journal of Clinical Investigation·A C HeringtonJ Stevenson
Jul 5, 2006·Urologic Oncology·David S Meinbach, Bal L Lokeshwar
Jun 1, 1988·Diabetes/metabolism Reviews·M Press
Dec 31, 1987·Biochemical and Biophysical Research Communications·T LinJ F Haskell
Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G H TeschA C Herington
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B D BoyanL D Swain
Oct 30, 1999·Archives of Andrology·R K Naz, P Padman
Apr 1, 1986·The American Journal of Physiology·J IsgaardO G Isaksson

Related Concepts

Fetal Structures
Novolin
Insulin Antagonists
Polypeptides
Hormone Receptors, Cell Surface
Somatomedins
Insulin-Like Growth Factor Receptor

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