Recent advances in the chemical synthesis of N-linked glycoproteins

Current Opinion in Chemical Biology
Unverzagt Carlo, Kajihara Yasuhiro

Abstract

Glycoproteins have many biological roles. Due to the heterogeneity of natural glycoproteins in the sugar part resulting in glycoforms the evaluation of the biochemical roles of individual glycans remains difficult to investigate. Since pure glycoforms are still not accessible via recombinant or chromatographic methods, the synthesis of proteins with uniform posttranslational modifications using ligation methods or glycan remodeling are currently the best options for accessing these targets. Recent developments in chemical protein synthesis, the assembly of N-glycans and the use of enzymatic procedures have provided access to many glycoproteins with modifications as well as their analogs.

Citations

Mar 30, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Claudia BelloAnna Maria Papini
Feb 6, 2020·Journal of Clinical Medicine·Rocío Fuertes-MartínNúria Amigó
Mar 7, 2020·Journal of Pediatric Gastroenterology and Nutrition·Rulan Jiang, Bo Lönnerdal
Jul 14, 2020·Chemistry, an Asian Journal·Junjie Desmond Lin, Xue-Wei Liu
Nov 30, 2019·Nature Communications·Hanne L P TytgatTimothy G Keys
Oct 28, 2020·Chemistry : a European Journal·Yukishige ItoYoichi Takeda
Feb 13, 2021·Journal of the American Chemical Society·Hongxing LiSuwei Dong
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Jul 1, 2021·Journal of the American Chemical Society·Kota NomuraYasuhiro Kajihara
Nov 26, 2020·Journal of Medicinal Chemistry·Vangelis AgouridasOleg Melnyk
Sep 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mingji LiMatthew P DeLisa
Sep 27, 2020·Nature Communications·Manuel Nieto-DomínguezMaría Jesús Martínez

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