Recent advances in the development of Mcl-1 inhibitors for cancer therapy

Pharmacology & Therapeutics
Alexander W Hird, Adriana E Tron

Abstract

Dysregulation of the mitochondrial apoptotic pathway controlled by members of the Bcl-2 protein family plays a central role in cancer development and resistance to conventional cytotoxic as well as targeted therapies. Hence, selective inhibition of pro-survival Bcl-2 family of proteins to activate apoptosis in malignant cells represents an exciting anti-cancer strategy. The remarkable clinical performance of the selective Bcl-2 antagonist venetoclax has highlighted the potential for selective inhibitors of the other pro-survival members of the Bcl-2 family, particularly Mcl-1. Here we review the latest progress on the discovery and development of selective inhibitors of Mcl-1 that are undergoing clinical evaluation for cancer therapy.

Citations

Oct 1, 2019·Expert Opinion on Therapeutic Patents·Steven Fletcher
Nov 8, 2019·Current Topics in Medicinal Chemistry·Bingbing LiYuanxiang Wang
Feb 23, 2020·Future Medicinal Chemistry·Xuan ZhangGuangrong Zheng
Jan 8, 2020·Cell Death and Differentiation·Viacheslav V SenichkinGelina S Kopeina
Jul 28, 2020·Future Oncology·Siti Fairus Abdul RahmanNethia Mohana-Kumaran
Jun 10, 2020·Cell Death & Disease·Nabanita MukherjeeYiqun G Shellman
Jul 29, 2020·Journal of Hematology & Oncology·Yonghan HeDaohong Zhou
Apr 27, 2020·Apoptosis : an International Journal on Programmed Cell Death·Prashanthi Ramesh, Jan Paul Medema
Dec 19, 2020·Cancer Biology & Therapy·Mi Jeong KimXingming Deng
Dec 29, 2020·Trends in Cancer·Dennis Juarez, David A Fruman
Nov 17, 2020·Gynecologic Oncology·Danielle C KimbleMichael L Maitland
Dec 1, 2020·Bioorganic & Medicinal Chemistry Letters·Kexue Li
Oct 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Estefanía LucendoMar Orzáez
Nov 5, 2020·Cell Death & Disease·Hayley WiddenWilliam J Placzek
Feb 9, 2021·Molecular & Cellular Oncology·Mónica Sancho, Mar Orzáez
Feb 28, 2021·Cell Death & Disease·Narissa ParryMhairi Copland
Mar 21, 2021·Biochemical Pharmacology·Manon LernouxMarc Diederich
Jul 1, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nir Shahar, Sarit Larisch
Feb 10, 2020·Bioorganic & Medicinal Chemistry Letters·Shelly Gapil TiamasFanny Roussi
Apr 23, 2021·Journal of Hematology & Oncology·Haolan WangYongheng Chen
Jan 1, 2020·Exploration of Targeted Anti-tumor Therapy·Peiyi ZhangGuangrong Zheng
Aug 3, 2021·International Journal of Biological Macromolecules·Pooja MittalIndrakant Kumar Singh
Oct 4, 2019·Journal of Medicinal Chemistry·Camille DenisAnne Sophie Voisin-Chiret
Aug 29, 2021·Pharmaceuticals·Chiara R DartYiqun G Shellman
Sep 18, 2020·Recent Patents on Anti-cancer Drug Discovery·Ying FanHao Fang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.