Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Min WuJinshan Guo

Abstract

Chronic wounds, such as pressure ulcers, vascular ulcers and diabetic foot ulcers (DFUs), often stay in a state of pathological inflammation and suffer from persistent infection, excess inflammation, and hypoxia, thus they are difficult to be healed. Nitric oxide (NO) plays a critical role in the regulation of various wound healing processes, including inflammatory response, cell proliferation, collagen formation, antimicrobial action and angiogenesis. The important role of NO in wound healing attracts intensive research focus on NO-based wound healing therapy. However, the application of NO gas therapy needs to resolve the intrinsic shortcomings of gas therapy, such as short storage and release times as well as temporal and spatial uncontrollability of the release mode. So far, various types of NO donors, including organic nitrates (RONO2), nitrites (RONO), S-nitrosothiols (RSNOs), nitrosamines, N-diazeniumdiolates (NONOates), and metal-NO complexes, have been developed to solidify gaseous NO and they were further encapsulated in or conjugated onto a variety of biomaterial vectors to develop NO delivery systems. NO synthetic enzyme mimics to catalyze the production and release of NO from L-arginine have also been developed. Th...Continue Reading

References

Aug 2, 1996·The Journal of Biological Chemistry·R J SinghB Kalyanaraman
Feb 19, 2002·Kidney International·Stefan FrankJosef Pfeilschifter
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk
Apr 27, 2002·American Journal of Surgery·Maria B Witte, Adrian Barbul
Apr 24, 2003·Journal of the American Chemical Society·Huiping ZhangMark E Meyerhoff
Feb 13, 2004·World Journal of Surgery·Majida RizkAdrian Barbul
Sep 21, 2004·Nature Reviews. Microbiology·Ferric C Fang
Feb 1, 2005·Journal of Biomedical Materials Research. Part a·Megan C Frost, Mark E Meyerhoff
Jun 30, 2005·Journal of the American Chemical Society·Aaron R RothrockMark H Schoenfisch
Jan 13, 2006·Journal of the American Chemical Society·Paul S WheatleyRussell E Morris
Jun 22, 2006·Journal of the American Chemical Society·Nathan A Stasko, Mark H Schoenfisch
Feb 1, 2007·Journal of the American Chemical Society·Bo XiaoRussell E Morris
Mar 23, 2007·Journal of the American Chemical Society·Jae Ho ShinMark H Schoenfisch
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Feb 6, 2008·Biomacromolecules·Nathan A StaskoMark H Schoenfisch
Feb 24, 2009·Biomaterials·Evan M HetrickMark H Schoenfisch
Aug 8, 2009·Journal of the American College of Cardiology·Shao-Ling HuangDavid D McPherson
Sep 22, 2009·Journal of the American Chemical Society·Yun Suk JoJeffrey A Hubbell
Sep 10, 2010·Journal of Vascular Surgery·Vickie R DriverGary Gibbons
Apr 19, 2011·Chemistry of Materials : a Publication of the American Chemical Society·Daniel A RiccioMark H Schoenfisch
Nov 5, 2011·Chemistry of Materials : a Publication of the American Chemical Society·Yuan LuMark H Schoenfisch
Jan 24, 2012·Journal of the American Chemical Society·Jacqueline L Harding, Melissa M Reynolds
Mar 1, 2012·Chemical Society Reviews·Daniel A Riccio, Mark H Schoenfisch
May 2, 2012·Virulence·David O SchairerAdam J Friedman
Sep 28, 2012·Biomacromolecules·Bin SunMark H Schoenfisch
Nov 9, 2012·Small·Noora NaghaviAlexander M Seifalian
Aug 7, 2013·ACS Applied Materials & Interfaces·Ahyeon KohMark H Schoenfisch
Nov 26, 2013·Biomaterials·Yuan LuMark H Schoenfisch
Apr 8, 2014·Biomaterials Science·Ying WangGuillermo A Ameer
Jun 19, 2014·Journal of Vascular Surgery·Caitlin W HicksChristopher J Abularrage
Jan 25, 2012·Advanced Functional Materials·Michele C JenGuillermo A Ameer
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Breanne MordorskiAdam J Friedman
Dec 3, 2014·Acta Biomaterialia·A LoweK J Balkus
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·John F QuinnThomas P Davis
May 11, 2015·International Journal of Biological Macromolecules·Jong Oh KimJin-Wook Yoo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
amputation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.