Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus

Biomolecules & Therapeutics
Xin LiChoong Jae Lee

Abstract

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the airway obstruction and the colonization of pathogenic microbes. Developing a novel pharmacological agent to regulate the production and/or secretion of pulmonary mucus can be a useful strategy for the effective management of pathologic hypersecretion of mucus observed in COPD and asthma. Thus, in the present review, we tried to give an overview of the conventional pharmacotherapy for mucus-hypersecretory diseases and recent research results on searching for the novel candidate agents for controlling of pulmonary mucus hypersecretion, aiming to shed light on the potential efficacious pharmacotherapy of mucus-hypersecretory diseases.

References

Jan 1, 1987·Respiration; International Review of Thoracic Diseases·J Germouty, J L Jirou-Najou
Oct 1, 1987·Chest·G H GuyattM T Newhouse
Jan 1, 1981·Respiration; International Review of Thoracic Diseases·L AllegraP C Braga
Feb 18, 1994·Science·C A VasconcellosT P Stossel
Jul 1, 1996·Trends in Pharmacological Sciences·C Bertrand, P Geppetti
Feb 19, 1999·Pediatric Pulmonology·B K Rubin
Jan 7, 2000·Biochemical and Biophysical Research Communications·M DesakiK Ito
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A NakanishiM Fujino
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Makoto HoshinoMasahiko Fujino
Jun 28, 2003·American Journal of Respiratory and Critical Care Medicine·Takeshi ShimizuYuichi Majima
Nov 1, 1964·The American Review of Respiratory Disease·A L SHEFFNERH P SARETT
Jan 13, 2004·Nature Medicine·Monique SingerKenneth B Adler
Feb 12, 2004·Chest·Jun Tamaoki
Feb 28, 2004·American Journal of Respiratory Cell and Molecular Biology·Markus O HenkeBruce K Rubin
Jun 29, 2004·The European Respiratory Journal·H P HauberQ Hamid
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Hans-Peter HauberQutayba Hamid
May 6, 2005·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Hans-Peter HauberQutayba Hamid
Apr 4, 2006·Annals of Medicine·Duncan F Rogers, Peter J Barnes
Oct 3, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ruoling GuoEdzard Ernst
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Markus O HenkeBruce K Rubin
Jan 31, 2007·Phytotherapy Research : PTR·Ho Jin HeoChoong Jae Lee
Apr 11, 2007·Paediatric Respiratory Reviews·Markus O Henke, Felix Ratjen
Jun 30, 2007·American Journal of Respiratory Cell and Molecular Biology·Hans-Peter HauberPeter Zabel
Jul 11, 2007·Journal of Endotoxin Research·Hans-Peter HauberPeter Zabel
Jul 12, 2007·Phytotherapy Research : PTR·Ho Jin HeoChoong Jae Lee
Jan 17, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Xue-Mei OuYan-Ping Li
Jan 9, 2009·The European Respiratory Journal·T WangF-Q Wen
Feb 10, 2009·Chest·Judith A Voynow, Bruce K Rubin

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
nuclear translocation

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
Duncan F Rogers
Recent Patents on Inflammation & Allergy Drug Discovery
Anurag AgrawalBalaram Ghosh
© 2021 Meta ULC. All rights reserved