Recent advances in the diagnosis of Lyme disease

Expert Review of Molecular Diagnostics
Alje P van Dam

Abstract

Diagnosis of human Lyme borreliosis is usually based on serology, which has a number of pitfalls. In the early phase of the disease serology can still be negative, whereas false-positive results are also common. The interpretation of confirmatory Western blot tests is not always easy. Furthermore, routine serology cannot discriminate between active and past infection. In addition, recombinant antigens are being introduced to improve serologic tests. New developments in the diagnosis of Lyme disease are the development of PCR tests. This review gives an overview of the molecular diagnostic possibilities of Lyme borreliosis, mainly by PCR, and describes some interesting possibilities for future serology.

References

Jan 1, 1995·The Journal of Investigative Dermatology·R WieneckeM Volkenandt
Feb 1, 1995·The Journal of Infectious Diseases·H EiffertF R Matuschka
Nov 1, 1994·Trends in Microbiology·M T Philipp, B J Johnson
Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A P van DamJ Dankert
Oct 1, 1993·Annals of Neurology·A R Pachner, E Delaney
Feb 1, 1993·The Journal of Infectious Diseases·F DresslerA C Steere
Jan 1, 1997·Journal of Clinical Microbiology·R K StraubingerM J Appel
Jan 1, 1997·Clinical Microbiology Reviews·B L Schmidt
Feb 12, 1998·Journal of Clinical Microbiology·G P WormserC Pavia
Jul 17, 1998·Clinical and Diagnostic Laboratory Immunology·P T FawcettR A Doughty
Jan 27, 1999·Journal of Medical Microbiology·R Kaiser, S Rauer
Mar 9, 1999·The Journal of Infectious Diseases·R T TrevejoD T Dennis
Apr 25, 2000·Medical Microbiology and Immunology·B WilskeU Schulte-Spechtel
Jun 2, 2000·Journal of Clinical Microbiology·J RobertsonJ Gray
Jul 14, 2001·The New England Journal of Medicine·A C Steere
Nov 9, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J NowakowskiUNKNOWN Lyme Disease Study Group

❮ Previous
Next ❯

Citations

Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raphael B Stricker
Jul 22, 2008·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Virginia R Savely
Nov 15, 2008·The Pediatric Infectious Disease Journal·Barbro Hedin SkogmanPia Forsberg
Oct 25, 2013·Expert Review of Molecular Diagnostics·Mark W EshooDavid J Ecker
Mar 11, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fabio TavoraRenu Virmani
Sep 10, 2003·Journal of the American Academy of Dermatology·Daniel E McGinley-Smith, Sandy S Tsao

❮ Previous
Next ❯

Related Concepts

Related Papers

Current Allergy and Asthma Reports
A R Marques
The New England Journal of Medicine
Neurology
K Sanders, J D Rogers
© 2022 Meta ULC. All rights reserved