Recent Advances in the Genetics of Schizophrenia

Molecular Neuropsychiatry
Dimitrios Avramopoulos

Abstract

The last decade brought tremendous progress in the field of schizophrenia genetics. As a result of extensive collaborations and multiple technological advances, we now recognize many types of genetic variants that increase the risk. These include large copy number variants, rare coding inherited and de novο variants, and over 100 loci harboring common risk variants. While the type and contribution to the risk vary among genetic variants, there is concordance in the functions of genes they implicate, such as those whose RNA binds the fragile X-related protein FMRP and members of the activity-regulated cytoskeletal complex involved in learning and memory. Gene expression studies add important information on the biology of the disease and recapitulate the same functional gene groups. Studies of alternative phenotypes help us widen our understanding of the genetic architecture of mental function and dysfunction, how diseases overlap not only with each other but also with non-disease phenotypes. The challenge is to apply this new knowledge to prevention and treatment and help patients. The data generated so far and emerging technologies, including new methods in cell engineering, offer significant promise that in the next decade we ...Continue Reading

References

Mar 1, 1977·Acta Psychiatrica Scandinavica·E Essen-Möller
Jan 1, 1977·Schizophrenia Bulletin·O Odegaard
Jan 1, 1991·European Archives of Psychiatry and Clinical Neuroscience·M McGue, I I Gottesman
Jan 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·I I Gottesman, J Shields
Jun 15, 1994·American Journal of Medical Genetics·E W ChowR Weksberg
Jan 1, 1996·Archives of General Psychiatry·E SusserJ M Gorman
Sep 13, 1996·Science·N Risch, K Merikangas
Oct 27, 1997·American Journal of Human Genetics·C CarlsonB E Morrow
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Nov 28, 2000·Annual Review of Genetics·L G Shaffer, J R Lupski
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Jan 23, 2003·Annals of the New York Academy of Sciences·Bertrand Jordan
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Nov 5, 2003·The British Journal of Psychiatry : the Journal of Mental Science·D IvanovM J Owen
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Nov 11, 2006·The Behavioral and Brain Sciences·Matthew C Keller, Geoffrey Miller
Apr 3, 2007·Journal of Medical Genetics·C DepienneA Brice
Nov 9, 2007·Human Molecular Genetics·George KirovReinhard Ullmann
Nov 22, 2007·Science·Junying YuJames A Thomson
Jan 11, 2008·The New England Journal of Medicine·Lauren A WeissUNKNOWN Autism Consortium
Feb 13, 2008·Molecular Psychiatry·R H Yolken, E F Torrey
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·W E LowryK Plath
May 31, 2008·Nature Genetics·Bin XuMaria Karayiorgou
Jun 19, 2008·Drug News & Perspectives·Karine R MayilyanRobert B Sim
Aug 1, 2008·Nature·UNKNOWN International Schizophrenia Consortium
Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Aug 5, 2008·Nature Genetics·Michael C O'DonovanUNKNOWN Molecular Genetics of Schizophrenia Collaboration
Oct 24, 2008·Human Molecular Genetics·Dan RujescuDavid A Collier
Jul 3, 2009·Nature·Hreinn StefanssonDavid A Collier
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar

❮ Previous
Next ❯

Citations

Mar 5, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ruirui ChenZhiqiang Li
Apr 23, 2020·Current Psychiatry Reports·Debamitra DasDimitrios Avramopoulos
May 8, 2020·Molecular Psychiatry·Robert G MealerJordan W Smoller
Jan 9, 2020·Psychodynamic Psychiatry·Guilherme Rui CantaCarlos Amaral Dias
Jun 20, 2019·Frontiers in Psychiatry·Davide AmatoAndreas Heinz
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Holly Landrum Peay
Oct 27, 2020·Frontiers in Psychiatry·Veronika LangovaJiri Horacek
Nov 3, 2020·Frontiers in Psychiatry·Silvia Sánchez-Ramón, Florence Faure
Mar 9, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xi PengDimitrios Avramopoulos
Apr 20, 2021·Biological Psychiatry·Myeong-Heui KimJeong Ho Lee
Oct 30, 2020·Current Medicinal Chemistry·Marcos Martínez-Banaclocha
Aug 10, 2021·Frontiers in Neuroscience·Yukio AgoJames A Waschek
Oct 19, 2021·Frontiers in Genetics·Chia-Hsiang ChenLieh-Yung Ping
Jan 16, 2019·Molecular Neuropsychiatry·Ming Li, Weihua Yue
Mar 31, 2021·Brain, Behavior and Evolution·Richard T Born, Gianluca M Bencomo
Dec 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vanessa Aguiar-PulidoM Elizabeth Ross
Dec 22, 2021·Cell Stress & Chaperones·Malgorzata KowalczykJan Kowalski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.