Recent Advances in the Histopathology of Drug-Induced Liver Injury

Surgical Pathology Clinics
David E Kleiner

Abstract

Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use.

Citations

Nov 24, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Lan WangXinyan Zhao
Aug 20, 2020·Der Pathologe·K ApelU Drebber
Aug 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Yan WangJidong Jia
Jun 4, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandra De JongheDean Naisbitt
Jul 24, 2021·Pathologica·Claudia CovelliMaria Guido
Aug 10, 2021·World Journal of Hepatology·Priyanka KamathSheetal D Ullal
Sep 11, 2021·Human Molecular Genetics·Martina ScanoDorianna Sandonà
Dec 16, 2021·Clinical Pharmacology and Therapeutics·Paul B Watkins

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