Recent advances in the management of systemic lupus erythematosus

F1000Research
Savino SciasciaMaria Laura Bertolaccini

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease presenting highly heterogeneous clinical manifestations and multi-systemic involvement. Patients are susceptible to relapse- and remission, thus making management challenging. Moreover, a considerable number of side effects may occur with conventional therapies; therefore, there is clearly a need for new therapeutic strategies. Since the pathogenesis of SLE is highly complex, it is far from being fully understood. However, greater understanding of the pathways and of the cellular and molecular mediators involved in SLE is being achieved. Emerging evidence has allowed the development of new biological therapeutic options targeting crucial molecular mediators involved in the pathogenesis of SLE. This literature review analyzes the availability of biological and target-directed treatments, phase II and III trials, and new therapies that are being developed for the treatment of SLE.

References

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Citations

Sep 12, 2019·Clinical and Experimental Immunology·M NewlingJ den Dunnen
Jun 17, 2020·Frontiers in Medicine·Marlene PlüßPeter Korsten
Aug 7, 2020·Expert Opinion on Investigational Drugs·Milena TocutGisele Zandman-Goddard
Oct 18, 2020·Annals of Surgical Oncology·Jessica BogachNicole J Look Hong

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Methods Mentioned

BETA
urine sediment

Clinical Trials Mentioned

NCT01773616
NCT01673295
NCT01639339
NCT02260934
NCT01632241
NCT01162681
NCT01395745
NCT02074020
NCT01972568
NCT00624338

Software Mentioned

LUNAR
EXPLORER
EMBLEM
NOBILITY

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