Recent advances in the management of gastrointestinal stromal tumors

Current Oncology Reports
Margaret von Mehren

Abstract

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and aberrant growth. Recently, tumors with platelet-derived growth factor receptor (PDGFR)-a mutations have been described in GISTs with wild-type KIT. Factors that predict for an unfavorable outcome are being recognized. A specific molecularly targeted drug, imatinib mesylate, has altered the treatment of this disease. The results of phase I, II, and III clinical trials have consistently demonstrated activity of this agent and elucidated the patient and tumor characteristics associated with response to imatinib. The current challenge in caring for these patients is to identify the appropriate clinical setting for treatment with imatinib and to define the approach to patients whose tumors are insensitive or refractory to imatinib.

References

Jul 27, 2001·Pathology International·S SakuraiM Fukayama
Aug 9, 2001·International Journal of Surgical Pathology·Angel Panizo-SantosJavier Pardo-Mindán
Aug 21, 2001·Surgery Today·Y TakahashiS Yokoyama
Oct 31, 2001·The American Journal of Surgical Pathology·M Miettinen, L H Sobin
Nov 14, 2001·Lancet·A T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichChristopher L Corless
Apr 11, 2002·European Journal of Gastroenterology & Hepatology·Shin IijimaTomoyuki Masuda
Apr 19, 2002·Digestive Surgery·Mohsen Shabahang, Alan S Livingstone
May 10, 2002·The American Journal of Pathology·Christopher L CorlessMichael C Heinrich
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Jul 3, 2002·Human Pathology·Ronald P DematteoGeorge Demetri
Jul 3, 2002·Human Pathology·Markku MiettinenJerzy Lasota
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Aug 29, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Peng LiGrace C H Yang
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel SingerJonathan A Fletcher
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Jan 17, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Allan T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Feb 4, 2003·Seminars in Hematology·Brian J Druker
Nov 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael LeahyUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

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Citations

Mar 2, 2006·BMC Bioinformatics·Ghislain BidautMichael F Ochs
Jun 23, 2004·Annals of the New York Academy of Sciences·Michael F OchsGarabet Toby
Nov 18, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Susan Chilton-MacneillSylvain Baruchel
Jan 13, 2006·The Oncologist·Robert S BenjaminBurton Eisenberg
Jan 16, 2010·Revista do Colégio Brasileiro de Cirurgiões·Rodrigo Pozza PintoLuis Fernando Moreira
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chi TarnAndrew K Godwin

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