Abstract
Neuroinflammation is associated with the pathogenesis of many neurological disorders including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and Huntington disease. Current studies in this area have advanced the mechanism of neuroinflammation and its role in neurodegeneration. Studies from epidemiologic, clinical and animal models also contributed in the various new mechanisms of neuroinflammation. In this line, activation of monocytes is an important emerging mechanism that has a, profound role in neuroinflammation and neurodegeneration. Ion channels, matrix metalloproteases and microRNAs are also found to be the key players in the pathogenesis of neuroinflammation. In particular, microRNA-32 regulates microglia-mediated neuroinflammation and thus neurodegeneration. Notably, some important studies describe the role of Th17 cells in neuroinflammation, but, very little knowledge is available about their mechanism of action. Particularly, the role of autophagy gets emphasized, which plays a very critical role in protein aggregation and neurodegeneration. In this review, we highlight and discuss the mechanisms of these mediators of inflammation by which they contribute to the disease progression. In concl...Continue Reading
Citations
Mar 5, 2019·Archives of Pharmacal Research·Yujeong LeeJaewon Lee
Jun 30, 2019·Journal of Cellular Physiology·Huaiqing LuoJin Xu
Apr 13, 2019·Current Topics in Medicinal Chemistry·Niraj Kumar JhaRituraj Niranjan
Sep 20, 2019·Acta Neuropathologica·Conceição BettencourtJanice L Holton
Sep 20, 2020·Annals of Clinical and Translational Neurology·Yu GuoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 28, 2020·Acta neurologica Belgica·Tamer YazarMurat Cihan
Jan 19, 2019·International Journal of Molecular Sciences·Francesco PotìIlaria Zanotti
Feb 8, 2019·Acta Pharmacologica Sinica·Ying ChenHong-Bo Wang
Apr 16, 2019·Frontiers in Neuroscience·James P BennettDavid G Brohawn
Aug 20, 2020·Journal of Molecular Neuroscience : MN·Zahra KiasalariMehrdad Roghani
Nov 30, 2019·Frontiers in Pharmacology·Fei LiuJuan Feng
May 14, 2020·BMC Complementary Medicine and Therapies·Nausheen NazirZia Uddin
May 16, 2019·Neural Regeneration Research·Bing-Wen LuLi-Ke Xie
Nov 24, 2019·Irish Journal of Medical Science·Hülya Olgun YazarDursun Kirbaş
May 19, 2020·Chemistry & Biodiversity·Wen-Cong YangYi Zhang
Nov 24, 2020·Journal of Neuroinflammation·Hyeon Joo HamJin Tae Hong
Jun 11, 2020·G3 : Genes - Genomes - Genetics·Martin L KatzLeslie A Lyons
Sep 1, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hülya Olgun YazarMurat Cihan
Jan 15, 2021·Animals : an Open Access Journal From MDPI·Fabiano J F de Sant'AnaMartí Pumarola
Jul 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rong-Rong ZhangShi-Jie Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Naila QayyumSangdun Choi
Sep 19, 2019·Journal of Neuroimmunology·Ying-Lin YangGuan-Hua Du
Oct 27, 2020·Frontiers in Neuroscience·Antony JustinB R Prashantha Kumar
Feb 27, 2021·Journal of Medical Virology·Rituraj NiranjanAshwani Kumar
May 11, 2021·Frontiers in Pharmacology·Ye PengNaihong Chen
May 31, 2021·Neurochemistry International·Charles Elias AssmannIvana Beatrice Mânica da Cruz
Jul 3, 2021·International Journal of Molecular Sciences·Edmundas Kaduševičius
May 6, 2020·Clinical Parkinsonism & Related Disorders·Emilia M GattoClaudia Perandones
Jul 25, 2021·International Journal of Molecular Sciences·Tapan BehlCiprian Brisc
Sep 11, 2021·Environmental Science and Pollution Research International·Heba M AbdouSaber Mohamed Eweda
Jan 6, 2022·Neurological Research·Yuequan ZhuYuchuan Ding