PMID: 11908768Mar 23, 2002Paper

Recent advances in the pharmacogenomics of thiopurine methyltransferase

The Pharmacogenomics Journal
S A Coulthard, A G Hall

Abstract

The thiopurine drugs (6-mercaptopurine, 6-thioguanine and azathioprine) are commonly used cytotoxic agents and immunosuppressants. One important route for the metabolism of these agents is methylation, mediated by thiopurine methyltransferase (TPMT). It is now well established that inter-individual variation in sensitivity to thiopurines can be due to the presence of common genetic polymorphisms affecting the TPMT gene. More recently variations in the number of tandem repeats in the 5' promoter region have been shown to influence TPMT expression in vitro. In this article, we review recent advances in the understanding of the range of inter-individual variation that may be involved in the open reading frame or promoter region of the TPMT gene. We also review the data which have been published regarding the influence such variations may have on both the clinical efficacy and toxicity of the thiopurine drugs.

References

May 2, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·R M WeinshilboumP A Pazmiño
Aug 1, 1989·Clinical Pharmacology and Therapeutics·L LennardR M Weinshilboum
Jan 1, 1995·Genetic Epidemiology·J P VuchetichR A Price
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·E Y KrynetskiW E Evans
Nov 16, 1996·BMJ : British Medical Journal·J S Lilleyman, L Lennard
Jan 1, 1997·The British Journal of Dermatology·A P JacksonJ McLelland
Mar 1, 1997·The British Journal of Dermatology·B B TanJ S English
Jul 1, 1997·Clinical Pharmacology and Therapeutics·D OtternessR Weinshilboum
Oct 21, 1998·European Journal of Biochemistry·M Y FessingW E Evans
Dec 1, 1998·British Journal of Pharmacology·C Spire-Vayron de la MoureyreF Broly
Feb 5, 1999·Human Molecular Genetics·M M AmeyawH L McLeod
Feb 5, 1999·Human Molecular Genetics·Y Y HonW E Evans
Sep 2, 1999·Pharmacogenetics·L GervotI de Waziers
Mar 22, 2000·Journal of the American Academy of Dermatology·S M TavadiaD N Sauder
Sep 8, 2000·Clinical Pharmacology and Therapeutics·L YanR M Weinshilboum

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Citations

Oct 3, 2007·Analytical and Bioanalytical Chemistry·Ioannis K LitosAchille Gravanis
Nov 4, 2005·Investigational New Drugs·Sally Coulthard, Linda Hogarth
Nov 30, 2006·Current Opinion in Gastroenterology·Irfan M HisamuddinVincent W Yang
Apr 30, 2003·Pharmacogenomics·J Steven Leeder
Jul 2, 2004·Therapeutic Drug Monitoring·James G Donnelly
Jan 17, 2003·Expert Review of Molecular Diagnostics·Andrew G HallJulie A E Irving
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Viet Hong PhanStephen J Clarke
Oct 13, 2007·Expert Opinion on Pharmacotherapy·Lea Cunningham, Richard Aplenc
Jun 23, 2004·British Journal of Clinical Pharmacology·Somrudee SrimartpiromWichittra Tassaneeyakul
Jun 6, 2008·Journal of Clinical Pharmacology·J Andrew WilliamsSteven A Wrighton
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·L J J DerijksD W Hommes
Dec 1, 2009·Heart Failure Clinics·Guinevere A MurphyMichael R Bristow
Aug 16, 2006·Journal of the American Academy of Dermatology·Akash A PatelCalvin O McCall
Dec 2, 2004·Nucleosides, Nucleotides & Nucleic Acids·S A CoulthardL A Hogarth
May 5, 2017·Pharmacogenomics·Zeina N Al-MahayriBassam R Ali
Mar 8, 2018·Clinical Pharmacokinetics·Luc J J DerijksAdriaan A van Bodegraven
Jul 13, 2004·Clinical Chemistry·Nicolas von AhsenMichael Oellerich

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