Recent Advances in the Pharmacological Management of Behavioral Disturbances Associated with Autism Spectrum Disorder in Children and Adolescents

Paediatric Drugs
Martine LamyCraig A Erickson

Abstract

Autism spectrum disorder (ASD) is a heterogeneous neuropsychiatric condition affecting an estimated one in 36 children. Youth with ASD may have severe behavioral disturbances including irritability, aggression, and hyperactivity. Currently, there are only two medications (risperidone and aripiprazole) approved by the US Food and Drug Administration (FDA) for the treatment of irritability associated with ASD. Pharmacologic treatments are commonly used to target ASD-associated symptoms including irritability, mood lability, anxiety, and hyperactivity. However, evidence for the efficacy of many commonly used treatments is limited by the lack of large placebo-controlled trials of these medications in this population. Research into the pathophysiology of ASD has led to new targets for pharmacologic therapy including the neuroimmune system, the endocannabinoid system, and the glutamatergic neurotransmitter system. The goal of this review is to provide an overview of the current evidence base for commonly used treatments, as well as emerging treatment options for common behavioral disturbances seen in youth with ASD.

References

Jan 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·R PerryJ E Overall
May 1, 1970·The American Journal of Psychiatry·G FaretraJ Dowling
Nov 1, 1996·Archives of General Psychiatry·C J McDougleL H Price
Aug 26, 1998·Anesthesiology·K L Bachenberg
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Oct 31, 2000·Journal of Autism and Developmental Disorders·B L HandenM Lubetsky
Jul 14, 2001·Journal of Autism and Developmental Disorders·K M BelsitoA W Zimmerman
Aug 8, 2001·The Journal of Clinical Psychiatry·E HollanderS Novotny
Oct 20, 2001·Journal of Child and Adolescent Psychopharmacology·D J PoseyC J McDougle
Aug 2, 2002·The New England Journal of Medicine·James T McCrackenUNKNOWN Research Units on Pediatric Psychopharmacology Autism Network
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric HollanderSerge Mosovich
Apr 24, 2003·Journal of Autism and Developmental Disorders·Andrés MartinLawrence Scahill
Jan 30, 2004·Diabetes Care·UNKNOWN American Diabetes AssociationUNKNOWN North American Association for the Study of Obesity
Dec 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric HollanderRupa Iyengar
Jan 18, 2005·Biological Psychiatry·Sylvie TordjmanYvan Touitou
Sep 30, 2005·Journal of Child and Adolescent Psychopharmacology·Jessica A HellingsEdwin H Cook
Oct 22, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Pieter W TroostPieter J Hoekstra
Nov 9, 2005·Archives of General Psychiatry·UNKNOWN Research Units on Pediatric Psychopharmacology Autism Network
Sep 28, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·L Eugene ArnoldYaser Ramadan
Oct 3, 2006·International Clinical Psychopharmacology·Stacey WassermanEric Hollander
Oct 31, 2006·Journal of Child and Adolescent Psychopharmacology·Eric HollanderSherie Novotny
Oct 31, 2006·Journal of Child and Adolescent Psychopharmacology·Lawrence ScahillBenedetto Vitiello
May 4, 2007·The American Journal of Psychiatry·Suad Kapetanovic
Feb 19, 2008·Brain & Development·Xue MingGeorge C Wagner
Jul 23, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Emily SimonoffGillian Baird
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric HollanderEvdokia Anagnostou
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elissar AndariAngela Sirigu
Jul 14, 2010·Sleep Medicine·Judith A OwensHal L Kirchner
Jul 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vala RezaeiShahin Akhondzadeh
Apr 22, 2011·Journal of Clinical Psychopharmacology·Laurène BeherecOlivier Guillin
Apr 27, 2011·Developmental Medicine and Child Neurology·Daniel A Rossignol, Richard E Frye
Jul 5, 2011·Pediatric Neurology·Hélène De LeersnyderMoshe Laudon
Nov 2, 2011·Journal of Child and Adolescent Psychopharmacology·Janet L KowalskiChristopher J McDougle
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Stephen JamesKatrina Williams
Dec 6, 2011·Journal of Child and Adolescent Psychopharmacology·Craig A EricksonChristopher J McDougle
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Katrina WilliamsDanielle M Wheeler

❮ Previous
Next ❯

Citations

Nov 25, 2020·Paediatric Drugs·Gregory L Holmes
Oct 23, 2020·The International Journal of Neuroscience·Ayhan BilgiçAli Ünlü
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lourdes Alvarez-ArellanoJuan Carlos Corona
Mar 12, 2021·Pharmacological Reports : PR·Priya JoonMilind Parle
Apr 9, 2021·Frontiers in Neuroscience·Zhihong LanTianyue Wang
Sep 8, 2021·Journal of Autism and Developmental Disorders·Erin HenneberryCraig A Erickson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Current Psychiatry Reports
Danielle A Baribeau, Evdokia Anagnostou
Expert Opinion on Pharmacotherapy
Robert E AccordinoChristopher J McDougle
Seminars in Pediatric Neurology
Robyn P Thom, Christopher J McDougle
© 2021 Meta ULC. All rights reserved