Recent advances in the synthesis of fluorinated compounds via an aryne intermediate

Organic & Biomolecular Chemistry
Matiur RahmanAlakananda Hajra

Abstract

The development of new methodologies for the synthesis of fluorinated organic molecules is in high demand due to their wide applications in agriculture and pharmaceutical sciences. Various strategies have been employed for this purpose for a long time. Arynes are well known synthetic intermediates and have gained the attention of synthetic chemists for the synthesis of various functionalized organic molecules. Consequently, these synthetic intermediates have been successfully employed in the synthesis of fluorinated organic moieties. Various useful fluorinated aromatic and heterocyclic molecules have been synthesized employing aryne intermediates. In this review, we will discuss all these methodologies developed in the last decade via aryne intermediates.

References

Feb 6, 2003·Angewandte Chemie·Hans Henning WenkWolfram Sander
Sep 16, 2004·Angewandte Chemie·Ioannis SapountzisPaul Knochel
Apr 5, 2005·Natural Product Reports·Kenneth W Bentley
Sep 22, 2005·Journal of the American Chemical Society·Zhijian Liu, Richard C Larock
Oct 18, 2005·Angewandte Chemie·Masaharu NakamuraEiichi Nakamura
Jul 19, 2006·Angewandte Chemie·Manfred Schlosser
Sep 29, 2007·Science·Klaus MüllerFrançois Diederich
Jan 17, 2008·Chemical Society Reviews·David O'Hagan
Jan 17, 2008·Chemical Society Reviews·Sophie PurserVéronique Gouverneur
Dec 25, 2009·CNS Drugs·Emma D Deeks, Gillian M Keating
Sep 28, 2012·The Journal of Organic Chemistry·Chun LuRichard C Larock
Oct 13, 2012·Nature·Thomas R HoyeBrian P Woods
Nov 8, 2012·Organic & Biomolecular Chemistry·Anton V DubrovskiyRichard C Larock
Dec 19, 2012·Nature Chemistry·Adam E Goetz, Neil K Garg
Feb 13, 2013·Journal of the American Chemical Society·Yuwen ZengJinbo Hu
Jun 6, 2013·Chemical Communications : Chem Comm·Sangwon SeoMichael F Greaney
Jul 4, 2013·Angewandte Chemie·Hiroto YoshidaKen Takaki
Apr 15, 2014·Organic Letters·José-Antonio García-López, Michael F Greaney
May 2, 2014·Chemistry : a European Journal·Yuwen Zeng, Jinbo Hu
Oct 11, 2014·Journal of the American Chemical Society·Jose M MedinaK N Houk
Oct 21, 2014·Chemical Communications : Chem Comm·Suguru YoshidaTakamitsu Hosoya
Dec 5, 2014·Chemical Reviews·Michael G Campbell, Tobias Ritter
Jan 24, 2015·The Journal of Organic Chemistry·Kamarul MonirAlakananda Hajra
May 8, 2015·Chemical Communications : Chem Comm·Martin PawliczekDaniel B Werz
Jul 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hideto Miyabe
Dec 18, 2015·Organic & Biomolecular Chemistry·Subhajit MishraAlakananda Hajra
Jun 22, 2016·Organic & Biomolecular Chemistry·Samir Z Zard
Aug 26, 2016·Accounts of Chemical Research·Sachin Suresh BhojgudeAkkattu T Biju
Feb 15, 2018·Chemical Communications : Chem Comm·Tony Roy, Akkattu T Biju
Jun 8, 2018·Chemical Communications : Chem Comm·Rong FanJiajing Tan

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Natural Product Reports
A Sutherland, C L Willis
Journal of Medicinal Chemistry
Benjamin M JohnsonNicholas A Meanwell
© 2021 Meta ULC. All rights reserved