Recent advances in the synthesis of rare sugars using DHAP-dependent aldolases

Carbohydrate Research
Aimin LiZijie Li

Abstract

The occurrence rates of non-communicable diseases like obesity, diabetes and hyperlipidemia have increased remarkably due to excessive consumption of a high-energy diet. Rare sugars therefore have become increasingly attractive owing to their unique nutritional properties. In the past two decades, various rare sugars have been successfully prepared guided by the "Izumoring strategy". As a valuable complement to the Izumoring approach, the controllable dihydroxyacetone phosphate (DHAP)-dependent aldolases have generally predictable regio- and stereoselectivity, which makes them powerful tools in C-C bond construction and rare sugar production. However, the main disadvantage for this group of aldolases is their strict substrate specificity toward the donor molecule DHAP, a very expensive and relatively unstable compound. Among the current methods involving DHAP, the one that couples DHAP production from inexpensive starting materials (for instance, glycerol, DL-glycerol 3-phosphate, dihydroxyacetone, and glucose) with aldol condensation appears to be the most promising. This review thus focuses on recent advances in the application of L-rhamnulose-1-phosphate aldolase (RhaD), L-fuculose-1-phosphate aldolase (FucA), and D-fructose...Continue Reading

Citations

Dec 10, 2020·International Journal of Biological Macromolecules·Muhammad Waheed IqbalWanmeng Mu
Jan 22, 2020·Journal of Agricultural and Food Chemistry·Zijie LiXiao-Dong Gao
Sep 1, 2021·Trends in Biotechnology·Seon-Hwa LeeDeok-Kun Oh
Dec 21, 2021·Chemical Society Reviews·Ulf HanefeldCaroline E Paul
Dec 31, 2021·Critical Reviews in Food Science and Nutrition·Wenli ZhangWanmeng Mu

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