Recent advances in the understanding and management of primary hyperparathyroidism

F1000Research
Melanie Goldfarb, Frederick R Singer

Abstract

Primary hyperparathyroidism is a hormonal disorder whose prevalence is approximately 1-2% in the United States of America. The disease has become more recognizable to clinicians in an earlier phase and, at present, patients can be diagnosed with "classic", "normocalcemic", "normohormonal", or "mild, asymptomatic" primary hyperparathyroidism. Surgery, with a focused parathyroidectomy when possible, or a four-gland exploration, is the only way to cure the disease. Cure is determined by use of intra-operative parathyroid hormone monitoring with long-term cure rates ranging from 90-95%. Newer adjuncts to surgery include CT or PET imaging and near-infrared immunofluorescence. This article highlights updates in parathyroid disease and advances in parathyroid surgery; it does not provide a comprehensive summary of the disease process or a review of surgical indications, which can be found in the AAES guidelines or NIH Symposium on primary hyperparathyroidism.

References

May 26, 1966·The New England Journal of Medicine·O Cope
Jan 20, 2005·Surgery·Jack M Monchik, Emre Gorgun
Nov 2, 2007·ANZ Journal of Surgery·Leigh W Delbridge, Fausto F Palazzo
Aug 28, 2014·The Journal of Clinical Endocrinology and Metabolism·John P BilezikianJohn T Potts
Oct 8, 2015·The Journal of Clinical Endocrinology and Metabolism·Donald J McMahonMarcella D Walker
May 29, 2016·Journal of the American College of Surgeons·Lucia De GregorioAntonia E Stephen
Aug 23, 2016·The Laryngoscope·William S DukeDavid J Terris
Oct 16, 2016·Endocrine·Monica JainArmando E Giuliano
Sep 9, 2017·Nature Reviews. Endocrinology·Marcella D Walker, Shonni J Silverberg
Oct 25, 2017·Annals of Surgical Oncology·Yuan TianJulie A Miller
Oct 29, 2017·The Journal of Surgical Research·Joseph R ImbusDavid F Schneider
Nov 16, 2017·AJR. American Journal of Roentgenology·Ahmad ParvinianGeoffrey B Johnson
Dec 13, 2017·Langenbeck's Archives of Surgery·Sarah L HillarySabapathy P Balasubramanian
Feb 28, 2018·Annals of Surgical Oncology·Moska HamidiMatthew A Nehs
Apr 27, 2018·World Journal of Surgery·Carolyn D SeibEmily Finlayson
Sep 25, 2018·The Journal of Clinical Endocrinology and Metabolism·Jane RiggKarin Lust
Nov 20, 2018·Best Practice & Research. Clinical Endocrinology & Metabolism·Janet Y Lee, Dolores M Shoback
Dec 19, 2018·Clinical Medicine Insights. Endocrinology and Diabetes·Alex DombrowskyCourtney J Balentine
Jan 23, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Filomena CetaniClaudio Marcocci
Jan 23, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Natalie E CusanoJohn P Bilezikian
Jan 25, 2019·Annals of Surgical Oncology·Malcolm H SquiresJohn E Phay

❮ Previous
Next ❯

Citations

Jun 29, 2021·Therapeutic Advances in Chronic Disease·Ana Kashfia Islam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.