Recent Advances in Triacylglycerol Mobilization by the Gut

Trends in Endocrinology and Metabolism : TEM
Changting XiaoGary F Lewis

Abstract

Dietary lipid absorption and lipoprotein secretion by the gut are important in maintaining whole-body energy homeostasis and have significant implications for health and disease. The processing of dietary lipids, including storage within and subsequent mobilization and transport from enterocyte cytoplasmic lipid droplets or other intestinal lipid storage pools (including the secretary pathway, lamina propria and lymphatics) and secretion of chylomicrons, involves coordinated steps that are subject to various controls. This review summarizes recent advances in our understanding of the mechanisms that underlie lipid storage and mobilization by small intestinal enterocytes and the intestinal lymphatic vasculature. Therapeutic targeting of lipid processing by the gut may provide opportunities for the treatment and prevention of dyslipidemia, and for improving health status.

Citations

Feb 26, 2019·Current Protocols in Mouse Biology·Chih-Wei KoPatrick Tso
Sep 11, 2019·The Journal of Nutrition·Heather A McCauley
Feb 6, 2020·Nature Reviews. Gastroenterology & Hepatology·Chih-Wei KoPatrick Tso
Feb 18, 2020·Frontiers in Physiology·Changting XiaoGary F Lewis
Aug 20, 2020·Journal of Food Biochemistry·Hye-Jin KimMi-Jeong Ahn
May 21, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Simon HoffmanKhosrow Adeli
Mar 27, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melanie A MarkovicPatricia L Brubaker
Jun 2, 2020·Frontiers in Endocrinology·Chris J PackardMarja-Riitta Taskinen
Nov 30, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cuiyuan JinYuanxiang Jin
Jun 27, 2020·Progress in Lipid Research·Rainer H Straub
May 20, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alyssa S ZembroskiKimberly K Buhman
Mar 21, 2021·Endocrine Reviews·Priska StahelGary Franklin Lewis
Jul 21, 2021·Annual Review of Nutrition·Alyssa S ZembroskiKimberly K Buhman

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