Recent advances in understanding DNA replication: cell type-specific adaptation of the DNA replication program

F1000Research
Antoine Aze, Domenico Maiorano

Abstract

DNA replication is an essential process occurring prior to cell division. Cell division coupled to proliferation ensures the growth and renewal of a large variety of specialized cell types generated during embryonic development. Changes in the DNA replication program occur during development. Embryonic undifferentiated cells show a high replication rate and fast proliferation, whereas more differentiated cells are characterized by reduced DNA synthesis and a low proliferation rate. Hence, the DNA replication program must adapt to the specific features of cells committed to different fates. Recent findings on DNA synthesis regulation in different cell types open new perspectives for developing efficient and more adapted therapies to treat various diseases such as genetic diseases and cancer. This review will put the emphasis on recent progress made in this field.

References

Feb 12, 2002·Nature Cell Biology·Seiji Tanaka, John F X Diffley
Jan 9, 2004·Current Biology : CB·Patrick H O'FarrellTin Tin Su
Mar 31, 2004·Experimental Cell Research·Domenico MaioranoMarcel Méchali
Jan 1, 2008·Molecular and Cellular Endocrinology·Jérôme Artus, Michel Cohen-Tannoudji
Jul 9, 2008·The Journal of Biological Chemistry·Zhiying You, Hisao Masai
Sep 19, 2008·Molecular Biology of the Cell·Prasanta K PatelNicholas Rhind
Dec 17, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Benjamin D PopeDavid M Gilbert
Mar 31, 2010·Genes & Development·Matthew L EatonDavid M MacAlpine
Sep 24, 2010·Nature Reviews. Molecular Cell Biology·Marcel Méchali
Dec 9, 2010·Cold Spring Harbor Symposia on Quantitative Biology·D M GilbertI Hiratani
Mar 2, 2011·Nature Genetics·Louise S BicknellAndrew P Jackson
Mar 11, 2011·PloS One·Philip G WongMark G Alexandrow
Feb 24, 2012·Nature Reviews. Molecular Cell Biology·Constance Alabert, Anja Groth
May 7, 2013·Journal of Cell Science·Mona YekezareJohn F X Diffley
Jul 11, 2013·Cold Spring Harbor Perspectives in Biology·Nicholas Rhind, David M Gilbert
Dec 3, 2013·Molecular Cell·Jeannine GerhardtCarl L Schildkraut
Apr 2, 2014·Cell Reports·Stefano MattarocciDavid Shore
Oct 15, 2014·Methods in Molecular Biology·Huzefa Dungrawala, David Cortez
Jan 4, 2015·The EMBO Journal·Sara K PowellDavid M MacAlpine
Jan 27, 2015·Annual Review of Pathology·Morgane Macheret, Thanos D Halazonetis
Feb 26, 2015·Nucleic Acids Research·Beatrice RondinelliGiovanni Tonon
Mar 5, 2015·Genes & Development·Courtney G SansamChristopher L Sansam
May 1, 2015·F1000prime Reports·John M UrbanSusan A Gerbi
May 23, 2015·Nature Reviews. Molecular Cell Biology·Michalis FragkosMarcel Méchali
Jul 22, 2015·The Journal of Cell Biology·William C DrosopoulosCarl L Schildkraut
Sep 12, 2015·Genome Research·Shankar P DasNicholas Rhind
Oct 6, 2015·Nature Structural & Molecular Biology·Yutaka KanohHisao Masai
Nov 2, 2015·Current Opinion in Cell Biology·Michael S KaretaMarius Wernig

❮ Previous
Next ❯

Citations

Mar 31, 2021·European Journal of Histochemistry : EJH·Zhiping Chen, Lanfeng Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
RepID
acetylation
electron cryomicroscopy

Software Mentioned

iPOND

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Jisheng ZhangElena Ezhkova
Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Pamela Rizk, Nick Barker
Experimental Cell Research
Abdelghani MazouziJoanna I Loizou
© 2022 Meta ULC. All rights reserved