Recent advances in understanding mesenchymal stromal cells

F1000Research
Erika RendraKaren Bieback

Abstract

Mesenchymal stromal cells (MSCs) are among of the most studied cell type for cellular therapy thanks to the ease of isolation, cultivation, and the high ex vivo expansion potential. In 2018, the European Medicines Agency finally granted the first marketing authorization for an MSC product. Despite the numerous promising results in preclinical studies, translation into routine practice still lags behind: therapeutic benefits of MSCs are not as satisfactory in clinical trial settings as they appear to be in preclinical models. The bench-to-bedside-and-back approach and careful evaluation of discrepancies between preclinical and clinical results have provided valuable insights into critical components of MSC manufacturing, their mechanisms of action, and how to evaluate and quality-control them. We sum up these past developments in the introductory section ("Mesenchymal stromal cells: name follows function"). From the huge amount of information, we then selected a few examples to illustrate challenges and opportunities to improve MSCs for clinical purposes. These include tissue origin of MSCs, MSC culture conditions, immune compatibility, and route of application and dosing. Finally, we add some information on MSC mechanisms of ac...Continue Reading

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Citations

Oct 20, 2020·Frontiers in Cell and Developmental Biology·Mehdi NajarHassan Fahmi
Oct 25, 2020·Stem Cell Research & Therapy·Angelo TrivisonnoGabriele Toietta
Dec 18, 2020·Frontiers in Cell and Developmental Biology·André CoelhoAna Colette Maurício
Jun 1, 2021·Stem Cells International·Zhuo ChangXiao-Ling Feng
Sep 24, 2021·Biotechnology and Applied Biochemistry·Zeinab RafieeFatemeh Khademi Moghadam

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