Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans

F1000Research
Sophie JoanisseStuart M Phillips

Abstract

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is foundational to the process of functional hypertrophy. Much of our current understanding of skeletal muscle hypertrophy can be attributed to the development and utilization of stable isotopically labeled tracers. We know that resistance exercise and sufficient protein intake act synergistically and provide the most effective stimuli to enhance skeletal muscle mass; however, the molecular intricacies that underpin the tremendous response variability to resistance exercise-induced hypertrophy are complex. The purpose of this review is to discuss recent studies with the aim of shedding light on key regulatory mechanisms that dictate hypertrophic gains in skeletal muscle mass. We also aim to provide a brief up-to-date summary of the recent advances in our understanding of skeletal muscle hypertrophy in response to resistance training in humans.

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Citations

Sep 29, 2020·Frontiers in Nutrition·Andrew T AskowNicholas A Burd
Nov 13, 2020·Journal of Applied Physiology·Robinson Ramírez-VélezAntonio García-Hermoso
Jan 29, 2021·International Journal of Sports Medicine·Witalo KassianoAlex Silva Ribeiro
Mar 21, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Daniel L PlotkinBrad J Schoenfeld
Apr 4, 2021·International Journal of Molecular Sciences·Steffen H RaunLykke Sylow
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Maria J A van Ingen, Tyler J Kirby

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