Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ting-Ting WanYing Su

Abstract

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and remains a major cause of preventable blindness among adults at working age. DR involves an abnormal pathology of major retinal cells, including retinal pigment epithelium, microaneurysms, inter-retinal oedema, haemorrhage, exudates (hard exudates) and intraocular neovascularization. Hyperglycemia is the driving force for the development of diabetic retinopathy. The exact cause of diabetic nephropathy is unknown, but various postulated mechanisms are: hyperglycemia, advanced glycosylation products, activation of cytokines. In this review article, we have discussed a number of diabetes-induced metabolites such as glucose, advanced glycation end products, protein kinase C and oxidative stress and other related factors that are implicated in the pathophysiology of the DR. An understanding of the biochemical and molecular changes especially early in the DR may lead to new and effective therapies towards prevention and amelioration of DR.

References

Jun 15, 2006·Antioxidants & Redox Signaling·Alison C CaveAjay M Shah
Jun 20, 2006·Cardiovascular Research·Masuko Ushio-Fukai
Jan 17, 2007·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Mehmet C MocanBora Eldem
Sep 4, 2008·Journal of Periodontology·George L King
Jun 26, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Mar 29, 2011·Biochimica Et Biophysica Acta·Sho-ichi YamagishiSeiya Okuda
Apr 20, 2011·British Journal of Pharmacology·Valerio Costa, Alfredo Ciccodicola
May 19, 2011·Current Diabetes Reports·Hongliang ZongAlan W Stitt
Aug 26, 2011·Reviews on Recent Clinical Trials·Rafael Simó, Cristina Hernández
Apr 24, 2012·Current Drug Delivery·Deepa PathakBhojraj Suresh
Jun 12, 2013·Current Medicinal Chemistry·M ChenA W Stitt
Sep 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yunpeng DuTimothy S Kern
Nov 30, 2013·Mediators of Inflammation·Snježana KaštelanSpomenka Ljubić
Dec 20, 2013·Journal of Clinical & Experimental Ophthalmology·Lalit P Singh
Dec 1, 2012·Journal of Ocular Biology, Diseases, and Informatics·Yashodhara SharmaShankar Madhav Natu
Oct 11, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liwei ZhangBaihua Chen

❮ Previous
Next ❯

Citations

Apr 16, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steve Harvey, Carlos G Martinez-Moreno
Oct 1, 2016·Oxidative Medicine and Cellular Longevity·Janusz BlasiakKai Kaarniranta
May 24, 2018·The European Journal of Neuroscience·Paula V SubiradaMaría C Sánchez
Feb 7, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaobing QianQianying Gao
Feb 7, 2018·International Ophthalmology·Krishi V PeddadaMarcella Nebbioso
Jul 28, 2016·Journal of Biomolecular Screening·Mayur Choudhary, Goldis Malek
Dec 6, 2019·European Journal of Ophthalmology·Elisabetta MiserocchiFrancesco Bandello
May 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bee Ling Tan, Mohd Esa Norhaizan
Dec 6, 2018·Journal of Cellular Physiology·Rana ShafabakhshZatollah Asemi
Apr 10, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sundar KrishnasamySrinivasan Vedantham
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Ying YangKe Yang
May 11, 2021·Critical Reviews in Food Science and Nutrition·Kristin KruegerMarietta Zille
Feb 18, 2020·Current Diabetes Reviews·Kaveri M Adki, Yogesh A Kulkarni
Jul 8, 2021·Journal of Clinical Laboratory Analysis·Jing Zhu, Xiang Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved