Recent Advances of Gold Compounds in Anticancer Immunity

Frontiers in Chemistry
Shuang YueShuang Wei

Abstract

In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.

References

Feb 1, 1975·Infection and Immunity·J W Measel
Apr 26, 1969·Nature·B RosenbergV H Mansour
Nov 1, 1996·Clinical Immunology and Immunopathology·S Hirohata
Jun 25, 1998·Biologicals : Journal of the International Association of Biological Standardization·B Merchant
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K I JeonD M Jue
Feb 13, 2001·The Journal of Clinical Investigation·Y Yamamoto, R B Gaynor
Dec 26, 2001·Chemical Reviews·C F Shaw III
Aug 7, 2002·British Journal of Pharmacology·Maria Pia RigobelloAlberto Bindoli
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia A BrownGordon J Freeman
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·P'ng Loke, James P Allison
May 20, 2003·Experimental & Molecular Medicine·Kye-Im JeonDae-Myung Jue
Jun 5, 2003·Expert Opinion on Pharmacotherapy·Jörg Thomas Hartmann, Hans-Peter Lipp
Oct 18, 2003·Journal of Cancer Research and Clinical Oncology·Shunroh OhtsukasaKenichi Sugihara
Feb 17, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I SternW Y Tseng
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Dec 21, 2005·The Journal of Experimental Medicine·Noelia CasaresGuido Kroemer
Oct 13, 2006·Biochemical and Biophysical Research Communications·Hyung S YounDaniel H Hwang
Feb 23, 2007·Archiv der Pharmazie·Ingo Ott, Ronald Gust
Feb 27, 2007·Free Radical Biology & Medicine·Christine MarzanoMaria Pia Rigobello
Aug 8, 2007·Clinical and Experimental Immunology·S HavarinasabP Hultman
Oct 5, 2007·Journal of Leukocyte Biology·Cecilia K ZetterströmHelena Erlandsson Harris
Jan 1, 1994·Metal-based Drugs·P J Sadler, R E Sue
Dec 24, 2010·Science Translational Medicine·Mark P ChaoIrving L Weissman
Nov 23, 2011·Current Pharmaceutical Design·Yoshihiro SuzukiChisei Ra
Feb 15, 2012·Molecular Pharmacology·Ute JungwirthWalter Berger
Apr 25, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yiting Liu, James R Connor
Sep 12, 2012·Inflammopharmacology·J M MadeiraA Klegeris
Oct 9, 2012·Chemical Society Reviews·Xiaoyong Wang, Zijian Guo
Oct 31, 2012·Cancer Research·Chih-Long ChangChien-Fu Hung
Nov 14, 2012·Chemical Society Reviews·Wukun Liu, Ronald Gust
Nov 20, 2012·Annual Review of Immunology·Guido KroemerLaurence Zitvogel
Apr 6, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mohan N PatelPromise A Dosi

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
X ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved