Recent advances with alkaline phosphatase isoenzymes and their inhibitors

Archiv der Pharmazie
Dana M ZaherJamshed Iqbal

Abstract

Alkaline phosphatases are found in different living species and play crucial roles in various significant functions, such as hydrolyzing a variable spectrum of phosphate-containing physiological compounds, contributing to DNA synthesis, bone calcification, and attenuation of inflammation. They are homodimeric enzymes; each subunit contains one magnesium ion and two zinc ions crucial for the catalytic activity of the enzyme. Alkaline phosphatases exist in four distinct isoenzymes (placental, intestinal, germ cell, and tissue nonspecific alkaline phosphatases), which are expressed by four different genes; each one of them has distinguished functions. Any disturbance in the gene expression of alkaline phosphatase eventually induces serious disease conditions. Thus, the need to explore new lead inhibitors has increased recently. In this literature review, we aim to investigate the role of alkaline phosphatase in different diseases and physiological conditions and to study the structure-activity relationships of recently reported inhibitors. We focused on the lead compounds reported in the last 5 years (between 2015 and 2019).

References

Jan 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Harris
Apr 1, 1987·Gut·J E CompstonJ Rhodes
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lovisa HessleJosé Luis Millan
Oct 10, 2002·The Journal of Biological Chemistry·Marie-Hélène Le Du, Jose Luis Millan
Sep 3, 2003·Tropical Medicine & International Health : TM & IH·M J SartoriS P de Fabro
May 1, 1965·Journal of Clinical Pathology·F C NEALES POSEN
Oct 15, 2003·Clinical Microbiology Reviews·S Janssens, R Beyaert
Jun 11, 2005·Journal of Molecular Biology·Paola LlinasMarie Hélène Le Du
Jun 16, 2006·Critical Care Medicine·Fuhong SuJean-Louis Vincent
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
May 10, 2007·Journal of Biomedicine & Biotechnology·Sérvio T StinghenBonald C Figueiredo
Nov 6, 2007·Trends in Immunology·Daniel S Straus, Christopher K Glass
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ross F GoldbergRichard A Hodin
Jun 14, 2008·Gastroenterology·Kaoru Geddes, Dana J Philpott
Jul 17, 2010·The Journal of Biological Chemistry·Miguel Díaz-HernándezJesús Avila
Apr 26, 2011·Journal of Pediatric Hematology/oncology·Giovanna Assis Pereira BoechatBonald C Figueiredo
Apr 20, 2013·Annals of Surgery·Sayeda Nasrin AlamRichard A Hodin
May 18, 2013·Nature Reviews. Immunology·Luke A J O'NeillAndrew G Bowie
Dec 7, 2013·Experimental & Molecular Medicine·Beom Seok Park, Jie-Oh Lee
Feb 11, 2014·Nutrition Reviews·Jean-Paul Lallès
Apr 12, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Madhu S MaloRichard A Hodin
Jun 27, 2014·Indian Journal of Clinical Biochemistry : IJCB·Ujjawal SharmaRajendra Prasad
Nov 20, 2014·The Journal of Physical Chemistry. B·Gabriela L Borosky
Feb 20, 2015·Mini Reviews in Medicinal Chemistry·Mariya al-Rashida, Jamshed Iqbal
Feb 25, 2015·Computational and Structural Biotechnology Journal·Álvaro Sebastián-SerranoMiguel Díaz-Hernández
Mar 17, 2015·PloS One·Marc F HoylaertsJosé Luis Millán
Jul 30, 2015·Sub-cellular Biochemistry·Miguel Diaz-HernandezJesús Avila
Oct 16, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H A FinkUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Oct 23, 2015·Organic & Biomolecular Chemistry·Mariia MiliutinaPeter Langer
Nov 23, 2015·Calcified Tissue International·José Luis Millán, Michael P Whyte
Feb 4, 2016·Stem Cells International·David EstèveDavid Magne
Feb 20, 2016·Nature Reviews. Endocrinology·Michael P Whyte
Apr 17, 2016·The Journal of Surgical Research·Jason Fawley, David M Gourlay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here