Recent Breakthroughs and Ongoing Limitations in Cryptosporidium Research

F1000Research
Seema BhalchandraHonorine D Ward

Abstract

The intestinal apicomplexan parasite Cryptosporidium is a major cause of diarrheal disease in humans worldwide. However, treatment options are severely limited. The search for novel interventions is imperative, yet there are several challenges to drug development, including intractability of the parasite and limited technical tools to study it. This review addresses recent, exciting breakthroughs in this field, including novel cell culture models, strategies for genetic manipulation, transcriptomics, and promising new drug candidates. These advances will stimulate the ongoing quest to understand Cryptosporidium and the pathogenesis of cryptosporidiosis and to develop new approaches to combat this disease.

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Sep 5, 2019·American Journal of Physiology. Cell Physiology·Anoop KumarPradeep K Dudeja
Mar 22, 2019·Frontiers in Microbiology·Shijing ZhangLihua Xiao
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Methods Mentioned

BETA
IEC
transmission electron microscopy
scanning electron microscopy
atomic force microscopy
confocal microscopy
transfection
transgenic
RNA-Seq
genetic

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