Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Ajeet Kumar SinghManjula Vinayak

Abstract

Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain relievers in present day practice as pain is mostly initiated due to inflammation. However, due to potentially serious side effects, long term use of these antihyperalgesic drugs raises concern. Therefore there is a demand to search novel medicines with least side effects. Herbal products have been used for centuries to reduce pain and inflammation, and phytochemicals are known to cause fewer side effects. However, identification of active phytochemicals of herbal medicines and clear understanding of the molecular mechanism of their action is needed for clinical acceptance. In this review, we have briefly discussed the cellular and molecular changes during hyperalgesia via inflammatory mediators and neuro-modulatory action involved therein. The review includes 54 recently reported phytochemicals with antihyperalgesic action, as per the literature available with PubMed, Google Scholar and Scopus. Compounds of high interest as potential antihyperalgesic agents are: curcumin, resveratrol, capsaicin,...Continue Reading

References

Sep 15, 2001·Nature·D Julius, A I Basbaum
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Camilla I Svensson, Tony L Yaksh
May 7, 2002·Life Sciences·Jorge E Torres-LópezVinicio Granados-Soto
Jul 20, 2002·Toxicology·Seiichiro FujisawaHiroshi Sakagami
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Otilia ObrejaMichaela Kress
Dec 17, 2002·Nature Medicine·Aris N EconomidesNeil Stahl
Sep 6, 2003·The Journal of Pharmacy and Pharmacology·Eun-Sil LeeJeon-Ok Moon
Dec 5, 2003·Nature Reviews. Drug Discovery·Linda R Watkins, Steven F Maier
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph R GhilardiPatrick W Mantyh
Apr 23, 2004·Trends in Biochemical Sciences·Yumi Yamamoto, Richard B Gaynor
Oct 7, 2004·Life Sciences·Ana P C VeigaJanetti N Francischi
Jan 6, 2005·Methods and Findings in Experimental and Clinical Pharmacology·Y K GuptaS Briyal
May 25, 2005·Brain Research·Hong Im KimJin-Ho Song
Aug 17, 2005·European Journal of Pharmacology·Reginald LiewPeter Collins
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Diana M BautistaPeter M Zygmunt
Nov 2, 2005·The Journal of Pharmacology and Experimental Therapeutics·Flavia Carla MeottiAdair R S Santos
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaochun Jin, Robert W Gereau
Apr 6, 2006·European Journal of Pharmacology·Sameer SharmaKanwaljit Chopra
Sep 26, 2006·Journal of Dental Research·C-K ParkS B Oh
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Sameer SharmaKanwaljit Chopra
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Jan 5, 2007·Biological & Pharmaceutical Bulletin·Sook-Jin LeeEui-Bae Jeung
Feb 23, 2007·Nature·Ellen A Lumpkin, Michael J Caterina
Mar 27, 2007·Biochemical Pharmacology·Gian Luigi Russo
Aug 28, 2007·Journal of Dental Research·H Y LiS B Oh
Sep 14, 2007·Molecular and Cellular Neurosciences·Susanne HensellekGisela Segond von Banchet
Dec 7, 2007·European Journal of Pain : EJP·Anurag KuhadKanwaljit Chopra
Apr 19, 2008·Neuroscience Letters·Maria Schäfers, Linda Sorkin
Jun 20, 2008·Archives of Pharmacal Research·Arnaldo Willain FilhoMárcia Maria de Souza

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Citations

Jan 9, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Zípora Morgana Quinteiro Dos SantosClaudriana Locatelli
Jan 21, 2021·European Journal of Medicinal Chemistry·Alessandro OrroPasqualina D'Ursi
Nov 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Héctor Isaac Rocha-GonzálezJesús Arrieta

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