Recent development of synthetic probes for detection of hypochlorous acid/hypochlorite

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Chenggong MaBaoxing Shen

Abstract

Hypochlorous acid/hypochlorite (HOCl/OCl-), as one of the most important reactive oxygen species (ROS), plays an important role in various physiological and pathological processes. Nonproperly located or abnormal concentration of OCl-, however, is associated with many diseases. Thus, developing the fluorescent probe for detecting OCl- is of great significance. To this end, in last decade, many fluorescent probes have been developed and applied for detecting HOCl/OCl- in vitro and in vivo. Despite a great progress has achieved, the development and application of near-infrared fluorescent HOCl/OCl- probe still have some challenges. For example, highly specific and sensitive NIR fluorescent HOCl/OCl- probes applied in endogenous OCl- detection and subcellular organelle bioimaging. In this review, we summarized the representative cases of HOCl/OCl- probes with properties that mentioned above. The discussion contains design strategies, detection mechanisms, as well as applications in bioimaging.

Citations

Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuyu Fang, Wim Dehaen
Dec 6, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yujing NieDianping Tang
Sep 26, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Pengjuan SunJing Liu
Apr 27, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tianran WangNao Xiao
Aug 27, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fang-Fang GuoZhi-Hong Xu
Sep 3, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Meltem AlpFatih Algi

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