Recent developments in childhood arterial ischaemic stroke

Lancet Neurology
Catherine Amlie-LefondHeather J Fullerton

Abstract

Stroke is increasingly recognised as a cause of childhood disability and lifelong morbidity: population-based estimates of the annual incidence of childhood stroke (ischaemic and haemorrhagic) range from 2.3 to 13.0 per 100,000 children, and incidence rates in neonates are closer to 1 per 5000 livebirths. Stroke in childhood can have many causes. Diagnosis is often delayed owing to low clinical suspicion and the need to exclude the frequent mimics of stroke in childhood. Outcomes are related to presentation, associated illnesses, the underlying cause, size, and location of the infarct, and stroke subtype, but more than a half of the children who have had a stroke will have long-term neurological sequelae. Furthermore, estimates of recurrence rates range from 6-19% in the first few years. Arteriopathy-including arterial dissection and other progressive and non-progressive arteriopathies-might account for up to 80% of childhood stroke in otherwise healthy children. Because children with cerebrovascular abnormalities are at the highest risk of recurrence (66% at 5 years), understanding of the nature and course of these arteriopathies is crucial to the development of secondary stroke prevention strategies.

References

Sep 1, 1991·Pediatric Neurology·M J LanskaD M Aram
Apr 1, 1986·Journal of Child Neurology·A DusserJ Aicardi
Oct 26, 1972·The New England Journal of Medicine·J A StockmanF A Oski
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jan 27, 1996·Lancet·V GanesanF J Kirkham
Jul 1, 1996·Journal of Child Neurology·H S AbramM J Painter
Apr 1, 1997·Journal of Child Neurology·J ManciniN Pinsard
Jun 1, 1997·Archives of Disease in Childhood·V Ganesan, F J Kirkham
Dec 31, 1997·Neurology·L S WilliamsJ Biller
Jan 17, 1998·Pediatrics·J LuttermanT Geva
Nov 3, 1998·Pediatric Radiology·R L RobertsonR M Scott
Feb 11, 1999·American Journal of Human Genetics·H IkedaT Arinami
May 26, 1999·Journal of Child Neurology·A Al-SulaimanG Magboll
Jul 15, 1999·Archives of Neurology·A J GrauW Hacke
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·T YamauchiM Fukui
Jun 1, 2000·Journal of Child Neurology·S ChabrierM Tardieu
Sep 6, 2000·Developmental Medicine and Child Neurology·V GanesanF J Kirkham
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·R AskalanG deVeber
Oct 17, 2001·Neurology·H J FullertonW S Smith
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Béatrice HussonGuillaume Sébire
Jul 10, 2002·Neurology·H J FullertonS C Johnston
Jul 12, 2002·Annals of Neurology·Mara PrenglerRobert J Adams
Nov 5, 2002·Pediatrics·Lidia V GabisNicholas J Lenn
Jan 31, 2003·Annals of Neurology·Vijeya GanesanFenella J Kirkham
Mar 1, 2003·Blood·M Catherine DriscollDonald Brambilla
Mar 5, 2003·British Journal of Haematology·Persis J AmroliaIrene A G Roberts
Mar 5, 2003·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Stéphane ChabrierMarc Tardieu
Apr 18, 2003·Pediatric Neurology·Sameiro BarreirinhoJosé Barbot
Jul 23, 2003·Neurology·Heather J FullertonS Claiborne Johnston
Aug 7, 2003·Journal of Pediatric Hematology/oncology·Lewis L HsuUNKNOWN Stroke Prevention Trial (STOP) and the Cooperative Study of Sickle Cell Disease (CSSCD)
Nov 25, 2003·Current Opinion in Pediatrics·Fenella J Kirkham

❮ Previous
Next ❯

Citations

May 7, 2010·Neuroradiology·Brynmor P JonesW Kling Chong
Feb 22, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Javier F CárdenasAdam Kirton
May 10, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Anastasia GkampetaEvangelos Pavlou
Jan 10, 2009·Indian Journal of Pediatrics·Pratibha Singhi
Dec 21, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sarah Murphy
May 28, 2009·Nature Reviews. Cardiology·Jose Biller
Dec 8, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Claire Allman, Richard B Scott
Dec 17, 2009·Plastic and Reconstructive Surgery·Matthew Brown, Charles Verheyden
Jul 11, 2009·Stroke; a Journal of Cerebral Circulation·Elizabeth PerkinsWarren Lo
Jun 3, 2011·Journal of Child Neurology·Warren D Lo
Sep 3, 2011·Journal of Neurosurgery. Pediatrics·Ji Hoon PhiSeung-Ki Kim
Mar 29, 2014·Pediatric Neurology·Ulrike Dunkhase-HeinlJohn R Ostergaard
Feb 19, 2011·Stroke Research and Treatment·Kay W P NgVijay K Sharma
Jan 19, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sarah E BuerkiUNKNOWN Swiss Neuropediatric Stroke Registry Study Group
Jul 11, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·O MonteventiJ Fluss
Jul 31, 2012·La Presse médicale·Guillaume Sébire
Mar 28, 2012·Brain & Development·Tetsuya KibeNobuo Okumura
Sep 15, 2009·Pediatric Neurology·Antonetta M G SasMarie Claire Y de Wit
Jan 18, 2012·European Journal of Clinical Investigation·Marisol Mirabelli-BadenierFabrizio Montecucco
Aug 9, 2011·Annals of Neurology·Sandra BigiMarcel Arnold
May 19, 2010·Developmental Medicine and Child Neurology·Sarah BuerkiMaja Steinlin
Mar 1, 2011·Acta Paediatrica·Gul SerdarogluSarenur Gokben
Oct 17, 2009·Acta Paediatrica·Meredith R GolombBhuwan P Garg
Jul 29, 2010·Expert Review of Neurotherapeutics·Andrew A Mallick, Finbar Jk O'Callaghan
Jun 28, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Charles EllisBruce Ovbiagele
Nov 14, 2008·Expert Opinion on Pharmacotherapy·Despina Eleftheriou, Vijeya Ganesan
Jun 11, 2015·BMC Neurology·Salome KornfeldSebastian Grunt
Apr 10, 2015·Current Treatment Options in Neurology·Maja Steinlin, Mark T Mackay
Jul 11, 2009·Expert Review of Cardiovascular Therapy·Despina Eleftheriou, Vijeya Ganesan
Nov 30, 2016·International Journal of Molecular Sciences·Clémence GuirautGuillaume Sébire
Jul 13, 2014·Journal of Child Neurology·Lalit R BansalGiulio Zuccoli
Feb 6, 2017·Continuum : Lifelong Learning in Neurology·Warren D Lo, Riten Kumar
Jan 5, 2013·Arquivos de neuro-psiquiatria·Karla Maria Ibraim da Freiria Elias, Maria Valeriana Leme de Moura-Ribeiro
Jun 14, 2013·Journal of Child Neurology·Christine A HajekWarren Lo
Oct 5, 2011·Journal of Child Neurology·Jared R Brosch, Meredith R Golomb
Aug 27, 2011·Stroke; a Journal of Cerebral Circulation·Colin M TurneyWarren Lo
Oct 16, 2018·Developmental Neuropsychology·Robyn WestmacottTricia S Williams
Nov 10, 2018·Developmental Medicine and Child Neurology·Victoria ShermanRosemary Martino
Mar 8, 2019·Journal of Magnetic Resonance Imaging : JMRI·Chih-Yang HsuJohn T Lucas
Dec 24, 2019·Stroke; a Journal of Cerebral Circulation·Aline RohnerSandra Bigi
Feb 7, 2017·Neurorehabilitation and Neural Repair·Anne-Laure MouthonReto Huber
Jul 29, 2020·Frontiers in Pediatrics·Martin SmitkaMaja von der Hagen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.