Recent developments in drug resistance and apoptosis research

May 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y LiangM Clynes

Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis.

Mar 31, 2015·Scientific Reports·Zhipeng WangQingyuan Zhang

Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line

Feb 27, 2009·Proteomics·Joanne KeenanMartin Clynes

Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs

Jul 9, 2004·International Journal of Cancer. Journal International Du Cancer·Yizheng LiangMartin Clynes

Episensitization: Defying Time's Arrow

Jul 1, 2015·Frontiers in Oncology·Bryan T OronskyTony R Reid

As2O3 toxicity in rat hepatocytes: manifestation of caspase-mediated apoptosis

Jan 15, 2009·Toxicology and Industrial Health·A RayS Bhattacharya

Evolution of resistance to targeted anti-cancer therapies during continuous and pulsed administration strategies.

Nov 7, 2009·PLoS Computational Biology·Jasmine Foo, Franziska Michor

Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA

Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·R NicAmhlaoibhM Clynes

Antibiotics: natural products essential to human health

Mar 18, 2009·Medicinal Research Reviews·Arnold L Demain

Comparison of maintenance energy requirement and energetic efficiency between lactating Holstein-Friesian and other groups of dairy cows

Dec 9, 2014·Journal of Dairy Science·L F DongD A McDowell

Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs

Sep 25, 2019·Antibiotics·Helene L Robertsen, Ewa M Musiol-Kroll

VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine

Aug 6, 2011·Microbiology·Fitria NingsihTakuya Nihira

Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.

Jul 21, 2020·BioMed Research International·Ghedeir M AlshammariAbdulrahman Al-Khalifa

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Recent developments in drug resistance and apoptosis research

Abstract

References

ABC transporters: from microorganisms to man

Multidrug resistance in human cancer

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

The ATP-dependent glutathione S-conjugate export pump

Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity

Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation

Apoptosis. A sticky business

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta

Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2.

Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents

Multidrug resistance and mutagenesis

Inactivation of Bcl-2 by phosphorylation

bcl-2 protein in invasive ductal breast carcinomas

Topoisomerase I in multiple drug resistance

Topoisomerase II in multiple drug resistance

Glutathione-related enzymes, glutathione and multidrug resistance

Pharmacologic circumvention of multidrug resistance

Human cell lines as models for multidrug resistance in solid tumours

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A Southwest Oncology Group study

The sequence of a cDNA encoding the major vault protein from Rattus norvegicus

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

Phosphorylation of the multidrug resistance associated protein gene encoded protein P190

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

Ribozyme-mediated reversal of the multidrug-resistant phenotype

Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators

Cellular models for multiple drug resistance in cancer

Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

Cell biological factors associated with the response of breast cancer to systemic treatment

Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma

Non-P-glycoprotein-mediated atypical multidrug resistance in a human bladder cancer cell line

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation

Trifluoperazine as a modulator of multidrug resistance in refractory breast cancer

Citations

Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract

Gamma-tocopheryl quinone stimulates apoptosis in drug-sensitive and multidrug-resistant cancer cells

Bcl-2 expression identifies patients with advanced bladder cancer treated by radiotherapy who benefit from neoadjuvant chemotherapy

A new monoclonal antibody, P2A8(6), that specifically recognizes a novel epitope on the multidrug resistance-associated protein 1 (MRP1), but not on MRP2 nor MRP3

Molecular markers of multiple drug resistance in breast cancer

Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness