Abstract
From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of western research fraternity in pharmaceutical potential of mushrooms. The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mushrooms credited with success against cancer belong to the genus Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. The anti-cancer compounds play crucial role as reactive oxygen species inducer, mitotic kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, leading to apoptosis, and eventually checking cancer proliferation. The present review updates the recent findings on the pharmacologically active compounds, their anti-tumor potential, and underlying mechanism of biological action in order to raise awareness for further investigations to develop cancer therapeutics from mus...Continue Reading
References
Sep 12, 2001·Mutation Research·R D DelmantoL R Ribeiro
Dec 1, 2001·Biochemical and Biophysical Research Communications·Y W LamH X Wang
Sep 5, 2002·Journal of Clinical Pharmacology·Kevin K W ChuAlbert H L Chow
Apr 5, 2003·Planta medica·Tzi Bun NgHexiang Wang
Oct 17, 2003·Life Sciences·In-Seon Lee, Akiyoshi Nishikawa
Feb 5, 2004·Journal of Agricultural and Food Chemistry·Jeong Hyun KimJong-Sang Kim
Jun 9, 2004·Journal of Ethnopharmacology·Sun-Hyoung KimEun-Hee Park
Nov 10, 2004·Cancer Letters·Ge LiWan-Hee Yoon
Mar 2, 2005·Cancer Letters·Yu-Huan Gu, Martha A Belury
Jan 18, 2006·Cancer Letters·Iris LaviBetty Schwartz
Aug 10, 2006·Mycologia·T B NgLixin Xia
Aug 26, 2006·Journal of Ethnopharmacology·Chiung-Chi PengHsiu Mei Hsieh-Li
Dec 8, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Feng-Jie CuiWen-Yi Tao
Feb 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ya-Ling HsuChun-Ching Lin
Mar 30, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·You-Cheng HseuHsin-Ling Yang
Apr 14, 2007·Molecular Biology Reports·Ben-Zion ZaidmanJamal Mahajna
Apr 21, 2007·Bioresource Technology·Maushmi KumariRekha S Singhal
Jun 26, 2007·Mycological Research·Jiezhong Chen, Robert Seviour
Jul 13, 2007·Bioresource Technology·Wei ChenYong-Quan Li
Oct 16, 2007·Journal of Ethnopharmacology·Tuzz-Ying SongMiao-Lin Hu
Oct 16, 2007·Journal of Ethnopharmacology·Ho Gyoung KimTae Woong Kim
Oct 27, 2007·Biochimica Et Biophysica Acta·Y R LiT B Ng
Nov 22, 2007·Cancer Letters·Mao YeYa Cao
Jan 8, 2008·Bioresource Technology·Cengiz SarikurkcuMustafa Yamac
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chien-Huang LiaoJiunn-Liang Ko
Jun 10, 2008·Fitoterapia·John R BakerSoon-Young Park
Jun 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·You-Cheng HseuHsin-Ling Yang
Jun 24, 2008·Journal of Ethnopharmacology·Chia-Yu ChangJiunn-Jye Chuu
Oct 18, 2008·The Journal of Nutritional Biochemistry·Ching-Han YuPaulus S Wang
Oct 22, 2008·Journal of Ethnopharmacology·Chun Sung KimDo Kyung Kim
Oct 28, 2008·Journal of Ethnopharmacology·Shih-Chung HsuMing-Ching Kao
Oct 29, 2008·Bioresource Technology·Haibin TongXin Sun
Nov 14, 2008·Nutrition and Cancer·Lynn S AdamsShiuan Chen
Dec 2, 2008·Journal of Ethnopharmacology·Myung-Ja YounRaekil Park
Dec 23, 2008·Biochimica Et Biophysica Acta·Jure PohlevenJoze Brzin
Dec 30, 2008·Toxicon : Official Journal of the International Society on Toxinology·J K ZhaoT B Ng
Jan 17, 2009·Journal of Bioscience and Bioengineering·Honghai HuNorio Sugiura
Jan 24, 2009·Journal of Ethnopharmacology·Chi-Fai KimClara Bik-San Lau
Mar 3, 2009·International Immunopharmacology·Yuki MasudaHiroaki Nanba
May 30, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Te-Ling LuYuh-Fung Chen
Jul 21, 2009·Chemico-biological Interactions·Fei-yan LiuTim-tak Kwok
Sep 3, 2009·Biochemical Pharmacology·Po-Cheng ChiangJih-Hwa Guh
Nov 17, 2009·International Immunopharmacology·Hui-Hsin ChangFuu Sheu
Dec 10, 2009·Journal of Ethnopharmacology·Yu-Yi ChanTing-Feng Wu
Apr 10, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G ZhangT B Ng
May 4, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyung Sook KimSang-Bae Han
Jun 18, 2010·Journal of Ethnopharmacology·Yeon Sil LeeJin-Kyung Kim
Jun 18, 2010·Cancer Letters·Jong Seok Lee, Eock Kee Hong
Jul 17, 2010·Journal of Acupuncture and Meridian Studies·Sang Eun ParkChong-Kwan Cho
Jul 17, 2010·Journal of Acupuncture and Meridian Studies·Kyung-Jun JangYung-Hyun Choi
Citations
Apr 25, 2013·Genetics and Molecular Research : GMR·V C FernandesA L Fachin
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Donna M Raditic, Joseph W Bartges
Sep 7, 2014·Biotechnology Advances·Katerina ZelenaRalf G Berger
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shang-Min ChouTang-Long Shen
Feb 9, 2016·Journal of Agricultural and Food Chemistry·Ching-Peng ChiuYang-Chang Wu
Feb 9, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Filipa S ReisM Helena Vasconcelos
Oct 2, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filipa S ReisM Helena Vasconcelos
Sep 16, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hye-Jin Park
Mar 12, 2015·Molecular Medicine Reports·Ming-Yang YehJing-Gung Chung
Feb 10, 2016·In Vitro Cellular & Developmental Biology. Animal·Napat RuamrungsriKorakot Nganvongpanit
Nov 18, 2015·Food & Function·Srishti RamsahaTheeshan Bahorun
Jan 19, 2016·Food Chemistry·Bożena MuszyńskaWłodzimierz Opoka
Jan 29, 2016·Mediators of Inflammation·Woo Seok YangJae Youl Cho
Sep 15, 2015·Journal of Ethnopharmacology·Jian-Hui LiuQi Tan
Apr 9, 2015·Medicinal Research Reviews·Alexander KornienkoRobert Kiss
Aug 19, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Han Gyung KimJae Youl Cho
Dec 3, 2014·Phytochemistry·Isabel C F R FerreiraMarina Sokovic
Feb 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ying WangLi-an Wang
Aug 31, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Haiyun ChenGeorge Pakheng Leung
Jul 3, 2013·International Journal of Biological Macromolecules·Kalimuthu SenthilkumarSe-Kwon Kim
Aug 20, 2014·Journal of Medicinal Food·Yvonne C O'CallaghanThomas J Smyth
Feb 17, 2015·International Journal of Microbiology·María Elena ValverdeOctavio Paredes-López
Nov 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Cheng-Han ChungKung-Ta Lee
Aug 28, 2016·BMC Complementary and Alternative Medicine·Ming-Yen TsaiKun-Ming Rau
May 24, 2017·Pharmaceutical Biology·Arisara PrateepChatchai Chaotham
Jan 19, 2017·Journal of Medicinal Food·Chia-Wei PhanVikineswary Sabaratnam
Jun 1, 2017·AAPS PharmSciTech·Jong Bong LeePavel Gershkovich
Nov 11, 2017·Critical Reviews in Biotechnology·Chia-Wei PhanVikineswary Sabaratnam
Oct 18, 2016·Food & Function·Limin ShiFeijun Luo
Dec 23, 2017·Oxidative Medicine and Cellular Longevity·M R RicciardiA Tafuri
Jun 5, 2018·Food & Function·Chaima BouzgarrouIsabel C F R Ferreira
Nov 14, 2018·Critical Reviews in Food Science and Nutrition·Xiao-Yin WangMing-Yong Xie
Feb 25, 2018·BMC Complementary and Alternative Medicine·Ha-Kyoung KwonHye-Jin Park
Feb 15, 2019·Scientific Reports·Anna MatuszewskaRenata Bancerz
Aug 8, 2019·Nutrition and Cancer·Chi H J KaoKaren S Bishop
Mar 1, 2020·Nutrients·Karen S Bishop
Sep 6, 2019·International Journal of Cancer. Journal International Du Cancer·Shu ZhangIchiro Tsuji
May 1, 2020·Food & Function·Yi YangJinyao Li
May 29, 2018·Oncotarget·Eliana Noelia AlonsoAlejandro Carlos Curino
May 5, 2020·Pharmaceutical Development and Technology·Omar Abu-Azzam, Maha Nasr
Feb 2, 2018·Biotechnology Journal·Junzhi WangHuanqing Niu
Jun 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filipa AntunesManuela Pintado
May 9, 2014·International Journal of Oncology·Jens C HahneArnd Honig
Jan 1, 2016·3 Biotech·Seema Patel
Dec 26, 2018·Journal of Cellular Physiology·Hsin-Ling YangYou-Cheng Hseu
May 30, 2019·BioMed Research International·Yu-Ri SeoKi-Taek Lim
Aug 29, 2019·Toxins·Ho Man Tang, Peter Chi Keung Cheung
Aug 27, 2019·Mycology·Omonike O OgboleMofolusho O Falade
Dec 19, 2019·Frontiers in Oncology·Stephanie I Nuñez-OlveraCésar López-Camarillo
Jul 29, 2020·Foods·SoonSil ChunInjun Han