Recent Developments in Preclinical DNA Vaccination

Vaccines
K OkudaMasaru Shimada

Abstract

The advantages of genetic immunization of the new vaccine using plasmid DNAs are multifold. For example, it is easy to generate plasmid DNAs, increase their dose during the manufacturing process, and sterilize them. Furthermore, they can be stored for a long period of time upon stabilization, and their protein encoding sequences can be easily modified by employing various DNA-manipulation techniques. Although DNA vaccinations strongly increase Th1-mediated immune responses in animals, several problems persist. One is about their weak immunogenicity in humans. To overcome this problem, various genetic adjuvants, electroporation, and prime-boost methods have been developed preclinically, which are reviewed here.

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Citations

Nov 19, 2015·Expert Opinion on Drug Delivery·Laure LambrichtGaëlle Vandermeulen
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May 30, 2015·Colloids and Surfaces. B, Biointerfaces·Ali Dehshahri, Hossein Sadeghpour
Aug 2, 2014·Veterinary Immunology and Immunopathology·Haiming CaiLinghua Zhang
Oct 31, 2016·Advanced Drug Delivery Reviews·Zeinab HosseinidoustMetin Sitti
Jan 31, 2017·Immunological Reviews·Bette KorberBeatrice H Hahn
Aug 4, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Pravin Shende, Vasavi Basarkar
Aug 16, 2019·Applied Microbiology and Biotechnology·Leila RahbarniaSayna Toraby
Oct 31, 2020·Human Vaccines & Immunotherapeutics·Lifeng LiHuiqing Sun
Nov 14, 2020·Journal of the Chinese Medical Association : JCMA·Cheng-Hsuan LiuYi-Ping Yang

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Methods Mentioned

BETA
transfection
gene gun
biopsy
biopsies

Software Mentioned

GenScript
Nanopatch

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