Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder-Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid-Liquid Phase Transitions.

Annual Review of Biophysics
Vladimir N Uversky

Abstract

This review deals with two important concepts-protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder-based biological liquid-liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.

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Citations

Aug 22, 2021·Journal of Molecular Biology·Kiersten M Ruff, Rohit V Pappu
Sep 15, 2021·Chemical Reviews·Fahmeed SheehanRein V Ulijn
Dec 31, 2021·Molecules and Cells·Yongdae Shin
Jan 31, 2022·Bioinformatics·Kirill E MedvedevNick V Grishin
Feb 11, 2022·Cell Biochemistry and Biophysics·Xianlong HuangYongqi Huang

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