Recent developments in the identification of novel oxazolidinone antibacterial agents

Bioorganic & Medicinal Chemistry
Adam R RensloMikhail F Gordeev

Abstract

The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and structure-activity relationships (SAR) are discussed in the context of earlier work in the field. Key issues of potency, spectrum, selectivity, in vivo efficacy, and pharmacokinetic profile of the new analogs are addressed.

References

Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·K HiramatsuF C Tenover
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Corinne J HackbarthZhengyu Yuan
Jan 10, 2003·Journal of Medicinal Chemistry·Michael R BarbachynMichael A Wynalda
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Lois M EdnieP C Appelbaum
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Mahesh V PatelPeter C Appelbaum
May 5, 2005·Bioorganic & Medicinal Chemistry Letters·Claude A QuesnelleJohn F Barrett
May 24, 2005·Bioorganic & Medicinal Chemistry Letters·Prasad P DixitNeelima Sinha
Jul 5, 2005·Expert Opinion on Investigational Drugs·D Shinabarger
Aug 5, 2005·Journal of Medicinal Chemistry·Noel J de SouzaHabil F Khorakiwala
Apr 29, 2006·Bioorganic & Medicinal Chemistry Letters·Adam R RensloMikhail F Gordeev

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Citations

Aug 24, 2007·Marine Biotechnology·Sofia OrtleppPeter Proksch
Feb 26, 2013·European Journal of Medicinal Chemistry·Ahmed KamalSoma Gupta
Jul 3, 2013·European Journal of Medicinal Chemistry·Cosimo G FortunaRosario Musumeci
Jul 3, 2013·European Journal of Medicinal Chemistry·Oludotun A PhillipsReny Varghese
Oct 9, 2013·European Journal of Medicinal Chemistry·Margherita De RosaAnnunziata Soriente
Jul 15, 2011·Acta Crystallographica. Section E, Structure Reports Online·Jin-Wu Zhao, Jing-Xiu Xu
Feb 18, 2014·Organic Letters·Santosh Kumar AlamsettiJan-E Bäckvall
May 6, 2014·European Journal of Medicinal Chemistry·Annavareddi NareshBatchu Venkateswara Rao
Mar 1, 2012·European Journal of Medicinal Chemistry·Antonio Palumbo PiccionelloAndrea Pace
Oct 12, 2007·Current Opinion in Microbiology·J V N Vara Prasad
Aug 26, 2009·Chemical Biology & Drug Design·Xiao-Jun WangLian-Quan Gu
May 5, 2012·Chemical Biology & Drug Design·Deepak BhattaraiGyochang Keum
May 25, 2012·Medicinal Research Reviews· Beena, Diwan S Rawat
Jun 7, 2014·Chemistry : a European Journal·Teemu NiemiTimo Repo
Jul 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto RomeoSalvatore V Giofrè
Nov 23, 2018·Organic & Biomolecular Chemistry· Preeti, Krishna Nand Singh
Jun 23, 2009·Archiv der Pharmazie·Xiao-Jun WangLian-Quan Gu
Jan 7, 2020·Topics in Current Chemistry·Ying ShiBin Zhao
May 16, 2009·Expert Opinion on Therapeutic Patents·Oludotun A Phillips, Leyla H Sharaf
May 17, 2012·Chemical Communications : Chem Comm·David Cruz CruzKarl Anker Jørgensen
May 12, 2010·Expert Review of Anti-infective Therapy·Adam R Renslo
Apr 20, 2017·Organic & Biomolecular Chemistry·Hélène LebelMatthias Ernzerhof
Feb 14, 2015·Chemical Biology & Drug Design·Yan ChenWei-Min Chen
Apr 4, 2014·Journal of Medicinal Chemistry·Mikhail F Gordeev, Zhengyu Y Yuan
Jun 23, 2020·ACS Pharmacology & Translational Science·Alexander WrightMatthew J Belousoff
Nov 21, 2017·ACS Medicinal Chemistry Letters·Mahesh S Deshmukh, Nidhi Jain

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