Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review

Current Atherosclerosis Reports
Jessica AyersDave L Dixon

Abstract

This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease. CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle. Although previous studies of CoQ10 for SAMS have produced mixed results, CoQ10 appears to be safe. Because CoQ10 is a cofactor in the generation of adenosine triphosphate, supplementation has also recently been studied in patients with heart failure, which is inherently an energy deprived state. The Q-SYMBIO trial found that CoQ10 supplementation in patients with heart failure not only improved functional capacity, but also significantly reduced cardiovascular events and mortality. Despite these positive findings, a larger prospective trial is warranted to support routine use of CoQ10. Less impressive are the effects of CoQ10 on specific cardiovascular risk factors such as blood pressure, dyslip...Continue Reading

References

May 1, 1991·British Heart Journal·J J BelchM Chopra
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K FolkersS A Mortensen
Jan 1, 1994·Molecular Aspects of Medicine·V DigiesiG P Littarru
Dec 9, 2003·The Journal of Physiology·Renée Ventura-ClapierVladimir Veksler
Jul 17, 2004·QJM : Monthly Journal of the Association of Physicians·G T Chew, G F Watts
May 17, 2005·BMJ : British Medical Journal·R Brian HaynesUNKNOWN Hedges Team
May 9, 2007·Mitochondrion·Salvatore PepeFranklin L Rosenfeldt
Jun 15, 2007·Journal of the American College of Cardiology·Leo Marcoff, Paul D Thompson
Jan 30, 2010·Parkinsonism & Related Disorders·M Flint Beal
Oct 4, 2011·Journal of Pharmacy & Bioallied Sciences·Rajiv Saini
Sep 18, 2012·European Journal of Internal Medicine·Aymelek GönençMeral Torun
Dec 12, 2012·The American Journal of Clinical Nutrition·A Domnica FotinoLydia A Bazzano
Jun 12, 2013·Journal of the American College of Cardiology·Clyde W YancyUNKNOWN American Heart Association Task Force on Practice Guidelines
Sep 21, 2013·The Cochrane Database of Systematic Reviews·Mohammed E MadmaniWaleed Kadro
Nov 7, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ajda SkarlovnikMišo Šabovič
Dec 3, 2014·Mayo Clinic Proceedings·Maciej BanachUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration Group
Dec 30, 2014·Atherosclerosis·Beth A TaylorPaul D Thompson
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

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Citations

Nov 2, 2018·Expert Review of Clinical Immunology·Masaru KatoTatsuya Atsumi
Feb 23, 2019·International Journal of Molecular Sciences·Garrison J B DyckJustin A Ezekowitz
Dec 26, 2018·Critical Reviews in Food Science and Nutrition·Uwe GröberKlaus Kisters
Aug 5, 2019·Current Clinical Pharmacology·Massumeh NiaziAlireza Moayyedkazemi
Jan 15, 2021·COPD·V I ZozinaA Corlateanu
Jan 21, 2020·Food Research International·Samad Ghaffari, Neda Roshanravan
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Marta Arenas-JalEncarna García-Montoya
Mar 7, 2021·Antioxidants·Žane Temova RakušaRobert Roškar
Apr 4, 2021·Biomedicines·Juan M Suárez-RiveroJosé A Sánchez-Alcázar
Aug 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Filomain NguemoJürgen Hescheler

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