Recent HIV-1 infection contributes to the viral diffusion over the French territory with a recent increasing frequency.

PloS One
P FrangeFrench ANRS CO6 PRIMO Cohort Study Group

Abstract

To analyse the contribution of primary human immunodeficiency virus type 1 (HIV-1) infection (PHI) to the French viral epidemic. HIV-1 pol sequences included 987 PHI from the French ANRS PRIMO cohort between 1999 and 2010 and were analysed using a population-based phylogenetic approach. Clinical features, risk factors, sexual behaviour and drug resistance for clustered and nonclustered transmission events were ascertained. Viruses from 125 (12.7%) of PHI cosegregated into 56 transmission chains, with increasing frequency during the last years (10.2% before 2006 versus 15.2% of clusters in 2006-2010, p = 0.02). The mean number of patients per cluster was 2.44. Compared to unique PHI, clusters involved more often men, infected through homosexual intercourse, of young age, with a high number of casual sexual partnerships and frequent previous HIV serological tests. Resistant strains were found in 16.0% and 11.1% of clusters and unique PHI, respectively (p = 0.11). Overall, 34% (n = 9) clusters included patients followed in French regions far apart, involving 13 clusters with at least one Parisian patient. PHIs are a significant source of onward transmission, especially in the MSM population. Recently infected people contribute to ...Continue Reading

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Jul 1, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ann M DennisMyron S Cohen
Dec 25, 2013·PloS One·Yazdan YazdanpanahA David Paltiel
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Jul 15, 2021·The Journal of Infectious Diseases·Jessy J Duran RamirezUNKNOWN Swiss HIV Cohort Study

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Methods Mentioned

BETA
ELISA
genotyping

Software Mentioned

Clustal W
MEGA4
BioEdit
PRIMO

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