RECENT IMPROVEMENTS IN SMALL ANGLE X-RAY DIFFRACTION FOR THE STUDY OF MUSCLE PHYSIOLOGY.

Reports on Progress in Physics
Massimo Reconditi

Abstract

The molecular mechanism of muscle contraction is one of the most important unresolved problems in Biology and Biophysics. Notwithstanding the great advances of recent years, it is not yet known in detail how the molecular motor in muscle, the class II myosin, converts the free energy of ATP hydrolysis into work by interacting with its track, the actin filament, neither it is understood how the high efficiency in energy conversion depends on the cooperative action of myosin motors working in parallel along the actin filament. Researches in muscle contraction imply the combination of mechanical, biochemical and structural methods in studies that span from tissue to single molecule. Therefore, more than for any other research field, progresses in the comprehension of muscle contraction at molecular level are related to, and in turn contribute to, the advancement of methods in Biophysics.This review will focus on the progresses achieved by time resolved small angle X-ray scattering (SAXS) from muscle, an approach made possible by the highly ordered arrangement of both the contractile proteins myosin and actin in the ca 2 mum long structural unit the sarcomere that repeats along the whole length of the muscle cell. Among the time re...Continue Reading

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Citations

May 30, 2015·International Journal of Molecular Sciences·Enrico Grazi
Sep 20, 2008·Current Opinion in Structural Biology·H Tsuruta, T C Irving
Sep 27, 2019·The Journal of General Physiology·Marco CaremaniMassimo Reconditi
Nov 9, 2019·The Journal of General Physiology·Weikang MaRoger Craig
Aug 21, 2020·The Journal of Physiology·Weikang MaMichael Regnier
Jul 15, 2016·Physical Review. E·M Caruel, L Truskinovsky
Jul 19, 2020·Biomechanics and Modeling in Mechanobiology·François Kimmig, Matthieu Caruel
Jun 27, 2017·Reports on Progress in Physics·M Caruel, L Truskinovsky
Jan 5, 2019·Biomechanics and Modeling in Mechanobiology·Matthieu CaruelDominique Chapelle
Jun 15, 2018·International Journal of Molecular Sciences·Hiroyuki Iwamoto
Sep 12, 2018·International Journal of Molecular Sciences·Weikang MaThomas Irving
Mar 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Elisabetta BrunelloMalcolm Irving
Jan 9, 2021·The Journal of General Physiology·Marco CaremaniElisabetta Brunello
Sep 30, 2018·Biophysical Journal·Weikang MaThomas Irving
Feb 28, 2021·Annual Review of Biophysics·Joseph D PowersThomas L Daniel
Jan 29, 2022·The Journal of General Physiology·Jesus G OvejeroElisabetta Brunello

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