Recent insights into endothelial control of leukocyte extravasation

Cellular and Molecular Life Sciences : CMLS
Peter L Hordijk

Abstract

In the process of leukocyte migration from the circulation across the vascular wall, the crosstalk with endothelial cells that line the blood vessels is essential. It is now firmly established that in endothelial cells important signaling events are initiated upon leukocyte adhesion that impinge on the regulation of cell-cell contact and control the efficiency of transendothelial migration. In addition, several external factors such as shear force and vascular stiffness were recently identified as important regulators of endothelial signaling and, consequently, leukocyte transmigration. Here, I review recent insights into endothelial signaling events that are linked to leukocyte migration across the vessel wall. In this field, protein phosphorylation and Rho-mediated cytoskeletal dynamics are still widely studied using increasingly sophisticated mouse models. In addition, activation of tyrosine phosphatases, changes in endothelial cell stiffness as well as different vascular beds have all been established as important factors in endothelial signaling and leukocyte transmigration. Finally, I address less-well-studied but interesting components in the endothelium that also control transendothelial migration, such as the ephrins a...Continue Reading

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Citations

May 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antje SchaeferPeter L Hordijk
Oct 6, 2016·F1000Research·Debashree Goswami, Dietmar Vestweber
Sep 7, 2019·Journal of Cell Science·Jisca MajoléePeter L Hordijk
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Feb 6, 2017·Cellular and Molecular Life Sciences : CMLS·Michael SchnoorAlexander Zarbock
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Apr 4, 2021·Biomedicines·Thijs J SluiterMargreet R de Vries
Apr 2, 2021·Life Sciences·Yuexian LiJin Zhang
Apr 29, 2021·Angiogenesis·Chiara CencioniFederico Bussolino

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