Recent insights into mitochondrial targeting strategies in liver transplantation

International Journal of Medical Sciences
Rui Miguel MartinsJosé Guilherme Tralhão

Abstract

Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mec...Continue Reading

Citations

Jul 16, 2020·International Journal of Molecular Sciences·João S TeodoroCarlos M Palmeira
Oct 18, 2018·Acta Cirúrgica Brasileira·Agnaldo Bruno ChiesOrlando Castro-E-Silva
Dec 29, 2020·Free Radical Biology & Medicine·Raúl P OliveiraAnabela P Rolo
Mar 5, 2021·Drug Delivery and Translational Research·Margarida Ferreira-SilvaMaria Luísa Corvo
Apr 4, 2021·International Journal of Molecular Sciences·Tamara HorváthPetra Hartmann
Sep 13, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naroa Goikoetxea-UsandizagaMaría Luz Martínez-Chantar

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