Recent insights into the biological activities and drug delivery systems of tanshinones

International Journal of Nanomedicine
Yuee CaiMeiwan Chen

Abstract

Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications.

Citations

Sep 1, 2016·Oxidative Medicine and Cellular Longevity·Yu-Chiang HungWen-Long Hu
Nov 4, 2016·Oxidative Medicine and Cellular Longevity·Cheng-Chieh ChangYu-Chiang Hung
Jun 27, 2020·Frontiers in Pharmacology·Elisa CeccheriniSilvia Rocchiccioli
Jul 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuang LiangYaxuan Sun
Jul 12, 2019·Journal of Cellular and Molecular Medicine·Weiguo WangJinglei Miao
Jan 28, 2021·Cancers·Alexander OuAmy B Heimberger
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sophia Ogechi EkeukuKok-Yong Chin
Sep 15, 2018·Molecular Pharmaceutics·Yuanliang YanZhijie Xu
Sep 18, 2021·Molecular and Cellular Biochemistry·Baoguo YeFei Wang

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