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Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk

BMC Medical Genetics

Oct 28, 2011

Matthew A SimonsonMatthew B McQueen

Abstract

Traditional genome-wide association studies are generally limited in their ability explain a large portion of genetic risk for most common diseases. We sought to use both traditional GWAS methods, as well as more recently developed polygenic genome-wide analysis techniques to identify s...read more

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
Systolic Blood Pressure Measurement
Total cholesterol
Ncbi Taxonomy
Serum Total Cholesterol Measurement
Genetic Pedigree
Etiology
Twin Studies
Cardiovascular Diseases
2
92
Paper Details
References
  • References41
  • Citations23
12345
  • References41
  • Citations23
123

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Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk

BMC Medical Genetics

Oct 28, 2011

Matthew A SimonsonMatthew B McQueen

PMID: 22029572

DOI: 10.1186/1471-2350-12-146

Abstract

Traditional genome-wide association studies are generally limited in their ability explain a large portion of genetic risk for most common diseases. We sought to use both traditional GWAS methods, as well as more recently developed polygenic genome-wide analysis techniques to identify s...read more

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
Systolic Blood Pressure Measurement
Total cholesterol
Ncbi Taxonomy
Serum Total Cholesterol Measurement
Genetic Pedigree
Etiology
Twin Studies
Cardiovascular Diseases
2
92

Similar Papers Found In These Feeds

Coronary Artery Disease

Coronary artery disease is extremely prevalent in western societies and is the number one cause of morbidity and mortality industrialized countries. Known risk factors include hypertension, smoking and dyslipidemia. Discover the latest research on coronary artery disease here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

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Nature Genetics

Common SNPs explain a large proportion of the heritability for human height

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American Journal of Human Genetics

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Paper Details
References
  • References41
  • Citations23
12345
  • References41
  • Citations23
123
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