PMID: 6989443Feb 1, 1980Paper

Recent observations on the serology of syphilis

The British Journal of Venereal Diseases
A LugerF Horn

Abstract

Routine screening of 404 742 sera by the automated micro-haemagglutination assay (AMHA-TP) and the Venereal Disease Research Laboratory (VDRL) test showed that 9848 specimens gave a reactive result to one of the three assays. Reactive results were confirmed by the fluorescent treponemal antibody absorption (FTA-ABS) test. The possibility of false-positive results varied from 0.04-0.38% of all specimens or from 1.7-15.7% of reactive sera. The VDRL test failed to detect reactivity in 56.54% of sera from patients who had previously been infected with Treponema pallidum. The importance of routine testing by the AMHA-TP is illustrated by the detection of four patients with mesaortitis and two with active neurosyphilis among a selected group of 54 patients who had non-reactive results to the VDRL test. Testing of cerebrospinal fluid specimens by the AMHA-TP test produced more specific results than by the other two tests.

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Citations

Aug 1, 1989·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P C GiniA N Njoku-Obi
Sep 1, 1986·Journal of the Neurological Sciences·E Kinnunen, M Hillbom
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Jun 1, 1981·The British Journal of Venereal Diseases·A LugerK Steyrer
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Aug 1, 1981·The British Journal of Venereal Diseases·A LugerE Schonwald
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Jun 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan TuddenhamKhalil G Ghanem

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