Recent omics technologies and their emerging applications for personalised medicine

IET Systems Biology
Dong-Hyuk KimAh-Ram Kim

Abstract

A major objective of 'omics' technologies is to understand genetic causality of complex traits of human diseases. High-throughput omics technologies and their application to medicine open up remarkable opportunities for realising optimised medical treatment for individuals. Because many major breakthrough and discoveries in this field have been driven by the development of new omics technologies, in this review, the authors aim to provide an in-depth description of their underlying principles as a foundation of developing another new omics technology, and to introduce their emerging applications for personalised medicine. The systems biology approach is then introduced as a future direction towards actionable personalised medicine.

Associated Clinical Trials

References

May 25, 1975·Journal of Molecular Biology·F Sanger, A R Coulson
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J KasianowiczD W Deamer
Aug 16, 1997·Lancet·Y M LoJ S Wainscoat
Jan 23, 1999·American Journal of Human Genetics·Y M LoN M Hjelm
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Feb 22, 2001·Science·J C VenterX Zhu
Mar 16, 2001·Breast Cancer Research : BCR·D F Easton
Jul 20, 2001·Molecular Genetics and Metabolism·G Bach
Sep 20, 2001·Seminars in Cancer Biology·S Sommer, S A Fuqua
May 16, 2002·Journal of the National Cancer Institute·Lanlan ShenJean-Pierre J Issa
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Stephan WaldmüllerHans Peter Vosberg
Aug 2, 2003·Methods : a Companion to Methods in Enzymology·Laura P O'Neill, Bryan M Turner
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Jan 8, 2004·Clinical Chemistry·K C Allen ChanY M Dennis Lo
Mar 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Maria CederholmOve Axelsson
Sep 22, 2005·Journal of the National Cancer Institute·Lanlan ShenJean-Pierre J Issa
Apr 29, 2006·The Journal of Molecular Diagnostics : JMD·Feras M HantashCharles M Strom
Mar 8, 2007·European Journal of Human Genetics : EJHG·Ansgar GerhardusDorothea Gadzicki
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining Chen, Giovanni Parmigiani
Apr 12, 2008·Trends in Molecular Medicine·Ryuya Yamanaka
Nov 7, 2008·Nature·David R BentleyAnthony J Smith
Nov 19, 2008·Nature Reviews. Genetics·Zhong WangMichael Snyder
Nov 22, 2008·Science·John EidStephen Turner
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rossa W K ChiuY M Dennis Lo
Jan 14, 2009·Cancer Prevention Research·Jean-Pierre Issa
Apr 8, 2009·Nature Methods·Emily H TurnerJay Shendure
May 16, 2009·Genomics·Norihiro TakeiUNKNOWN Japanese Genetic Study Consortium for Alzheimer Disease
Sep 9, 2009·Nature Reviews. Genetics·Peter J Park

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Citations

Jun 8, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·B A KonkleUNKNOWN My Life Our Future programme
Jul 18, 2021·Acta neurochirurgica·Sami Abu HamdehNiklas Marklund

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