Recent patents and trends in orally disintegrating tablets

Recent Patents on Drug Delivery & Formulation
Farhan AlhusbanAfzal R Mohammed

Abstract

Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones.

Citations

Jul 22, 2014·Expert Opinion on Drug Discovery·Ali Al-Khattawi, Afzal R Mohammed
Sep 26, 2015·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament
Mar 10, 2015·Chemical & Pharmaceutical Bulletin·Yasunori IwaoShigeru Itai
Jun 23, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Farhan AlhusbanAfzal R Mohammed
Sep 16, 2014·Pharmaceutical Development and Technology·Ulrike StangeHenning Gieseler
Jun 13, 2016·Journal of Pharmaceutical Sciences·Ellen V Hackl, Irina Ermolina
Nov 11, 2015·Scientific Reports·Jasdip S KonerAfzal R Mohammed

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