Recent pharmacological developments in the treatment of perennial and persistent allergic rhinitis

Expert Opinion on Pharmacotherapy
Ludger KlimekWytske Fokkens

Abstract

Allergic rhinitis (AR) has a major negative impact on patients' quality of life (QoL) and carries a high socio economic burden. This is particularly the case for patients who experience symptoms for extended periods of time (i.e. those with perennial (PAR) or persistent AR (PER), depending on the classification system used). This review covers available pharmacological advances and recent developments in the treatment of PAR or PER. Pharmacological AR treatment is used to reduce symptom burden and help restore patients' normal daily routine. Traditionally, non-sedating antihistamines and intranasal corticosteroids (INS) were the two drug classes recommended for use first line. These, along with antileukotrienes, decongestants, mast cell stabilizers and anticholinergics, constituted the bulk of the AR treatment arsenal. MP-AzeFlu (Dymista®, Meda, Solna, Sweden) is the most recent addition to that arsenal. It is a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) delivered in a single spray and has surpassed available therapies in terms of symptom control and treatment response. Other relatively new treatments for PAR or PER include H3 antihistamines, toll-like receptor (TLR) agonists,...Continue Reading

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Citations

Nov 16, 2018·Expert Opinion on Pharmacotherapy·Ludger KlimekPeter Valentin Tomazic
Sep 2, 2017·Expert Review of Respiratory Medicine·Todor A PopovMartin Church
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Dec 4, 2020·International Immunopharmacology·Shaobing XieWeihong Jiang

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