Recent Progress and Advances in Stimuli-Responsive Polymers for Cancer Therapy

Frontiers in Bioengineering and Biotechnology
N Vijayakameswara RaoJae Hyung Park

Abstract

The conventional chemotherapeutic agents, used for cancer chemotherapy, have major limitations including non-specificity, ubiquitous biodistribution, low concentration in tumor tissue, and systemic toxicity. In recent years, owing to their unique features, polymeric nanoparticles have been widely used for the target-specific delivery of drugs in the body. Although polymeric nanoparticles have addressed a number of important issues, the bioavailability of drugs at the disease site, and especially upon cellular internalization, remains a challenge. A polymer nanocarrier system with a stimuli-responsive property (e.g., pH, temperature, or redox potential), for example, would be amenable to address the intracellular delivery barriers by taking advantage of pH, temperature, or redox potentials. With a greater understanding of the difference between normal and pathological tissues, there is a highly promising role of stimuli-responsive nanocarriers for drug delivery in the future. In this review, we highlighted the recent advances in different types of stimuli-responsive polymers for drug delivery.

References

Jan 1, 1980·Oncology·C PragaR Labianca
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
Jul 25, 2003·Chemical Communications : Chem Comm·Elizabeth R Gillies, Jean M J Fréchet
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Seong LeeYou Han Bae
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudaxshina Murdan
Mar 3, 2004·Nature Materials·Alessandro NapoliJeffrey A Hubbell
Apr 7, 2004·Advanced Drug Delivery Reviews·Karel Ulbrich, Vladimír Subr
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haruhiko KamadaTadanori Mayumi
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Sep 8, 2004·Advanced Drug Delivery Reviews·Lisa Brannon-Peppas, James O Blanchette
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·José M EstrelaElena Obrador
Aug 11, 2006·Nature Reviews. Cancer·Ruth Duncan
Aug 23, 2006·Cancer Chemotherapy and Pharmacology·Scott A ShafferJack W Singer
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Dec 8, 2006·Nucleic Acids Symposium Series·Kazunori KataokaYukio Nagasaki
Nov 21, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lars H LindnerRolf D Issels
Jun 10, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Seong LeeYou Han Bae
May 30, 2009·Nature Reviews. Drug Discovery·Dunyaporn TrachoothamPeng Huang
Jan 26, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pilar Rivera GilWolfgang J Parak
Jan 29, 2010·Chemical Reviews·Jonathan F LovellGang Zheng
Jun 4, 2010·Molecular Pharmaceutics·Tomás EtrychKarel Ulbrich
Jul 29, 2010·Nanomedicine·Sarah R MacEwanAshutosh Chilkoti
Aug 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Sep 21, 2010·Advanced Materials·Yongfeng ZhouDeyue Yan
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Feb 15, 2011·International Journal of Pharmaceutics·Yanjun ZhaoZheng Wang
Feb 23, 2011·Chemistry : a European Journal·Chao WangXi Zhang
May 19, 2011·Macromolecular Rapid Communications·Haizheng ZhaoLin Yue Lanry Yung
Nov 15, 2011·Colloids and Surfaces. B, Biointerfaces·Ki Young ChoiKinam Park
Nov 24, 2011·Biomacromolecules·Vijayakameswara Rao NRaja Shunmugam
May 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·You Qiang YangLi Juan Zhang
May 15, 2012·Advanced Drug Delivery Reviews·P Couvreur
May 17, 2012·Biointerphases·Etienne CabaneWolfgang Meier
Jun 12, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Michael L EtheridgeJeffrey McCullough
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yali WuZhiyuan Zhong
Aug 8, 2012·Antioxidants & Redox Signaling·Joseph R BurgoynePhilip Eaton

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Citations

Nov 21, 2019·Macromolecular Bioscience·Yue WangZhaohui Tang
Jun 26, 2020·Angewandte Chemie·Mohamed FaresPhilip A Gale
Sep 25, 2020·Expert Opinion on Drug Delivery·Joydeb Majumder, Tamara Minko
Nov 30, 2018·Frontiers in Bioengineering and Biotechnology·Fernando Soto, Robert Chrostowski
Jan 24, 2019·Frontiers in Chemistry·Saziye Yorulmaz AvsarCornelia G Palivan
Oct 3, 2020·Pharmaceutics·N Vijayakameswara RaoJae Hyung Park
Aug 21, 2020·Expert Opinion on Drug Delivery·Estefânia Vangelie Ramos CamposDaniele Ribeiro de Araujo
Nov 13, 2019·Seminars in Cancer Biology·Sibi RajDhruv Kumar
Nov 7, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Patrícia F MonteiroCameron Alexander
Mar 7, 2021·Pharmaceutics·Mahsa Keihan ShokoohSimmyung Yook
Mar 9, 2021·Neurochemistry International·Mukta AgrawalAmit Alexander
Apr 1, 2021·Journal of Biomaterials Science. Polymer Edition·Md Mohosin Rana
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Liuhui ZhangJun Pang
May 11, 2021·Frontiers in Chemistry·Fengxiang Gao, Zhengrong Xiong
Jun 25, 2021·International Journal of Nanomedicine·Yongjia HuangJingqing Zhang
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Di ChangShenghong Ju
Jul 25, 2021·International Journal of Molecular Sciences·Przemyslaw WielgatHalina Car
Jul 24, 2021·Chemistry, an Asian Journal·Parvathy VenuRaja Shunmugam
Sep 9, 2021·Molecular Pharmaceutics·Sandeep PalvaiYevgeny Brudno
Jan 19, 2022·Expert Opinion on Drug Delivery·Prabakaran AAmit Alexander

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