Recent Progress and Future Perspectives of Antibiofilm Drugs Immobilized on Nanomaterials

Current Pharmaceutical Biotechnology
Fazlurrahman KhanYoung-Mog Kim

Abstract

A novel strategy has been adapted to combat the threat caused by biofilm forming-pathogenic bacteria in our environments. It involves the synthesis of antibiofilm compounds biologically (metabolites from animals, microbes and plants) and chemically. As a result of extensive research, a significant number of antimicrobial compounds and biofilm inhibitors have been isolated and characterized from different biological and chemical sources. However, lots of limitations such as poor delivery, water-insolubility, stability, expulsion by efflux pumps, and the development of acquired resistance due to long-term exposure have been associated with these compounds. Conjugation or encapsulation of these antibiofilm drugs with different biocompatible, biodegradable, chemically and thermally stable nanomaterials results in enhanced efficiency of biofilm inhibition. This review article evaluates the current impact of antibiofilm drugs including its delivery, efficiency of blocking cell attachment and molecular mechanisms of action that is conjugated or encapsulated with different types of biocompatible nanomaterials. It will lead to a better understanding of the antibiofilm drugs and their role in combating biofilms. It will also open new doo...Continue Reading

Citations

Mar 12, 2019·Current Pharmaceutical Biotechnology·Mulugeta MulatFazlurrahman Khan
Nov 14, 2019·Current Pharmaceutical Biotechnology·Fazlurrahman KhanYoung-Mog Kim
Jun 30, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Dung Thuy Nguyen PhamYoung-Mog Kim
Jan 24, 2020·Applied Microbiology and Biotechnology·Fazlurrahman KhanYoung-Mog Kim
Apr 14, 2020·International Journal of Nanomedicine·Alexandru-Flaviu TăbăranLucian Mocan
Aug 21, 2020·Applied Microbiology and Biotechnology·Fazlurrahman KhanYoung-Mog Kim
Oct 9, 2020·Biofouling·Fazlurrahman KhanYoung-Mog Kim
Apr 27, 2021·Applied Microbiology and Biotechnology·Fazlurrahman KhanYoung-Mog Kim
May 19, 2021·Critical Reviews in Microbiology·Fazlurrahman KhanYoung-Mog Kim

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