Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry

Journal of Labelled Compounds & Radiopharmaceuticals
C Taddei, Antony D Gee

Abstract

[11 C]Carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) are 2 attractive precursors for labelling the carbonyl position (C═O) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised 11 C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary 11 C-precursor production and uses, the review focuses on recent progress with direct 11 C-carboxylation routes with [11 C]CO2 and 11 C-carbonylation with [11 C]CO. Novel approaches to generate [11 C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [11 C]CO production methods. These innovative [11 C]CO synthesis strategies represent efficient and reliable [11 C]CO production processes, enabling the widespread use of [11 C]CO chemistry within the wider radiochemistry community.

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Citations

May 10, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Ryan A BraggCharles S Elmore
Jun 3, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Dennis U NielsenTroels Skrydstrup
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Jun 18, 2020·Nuclear Medicine and Biology·Toshimitsu FukumuraMing-Rong Zhang
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Jan 29, 2021·Journal of the American Chemical Society·Duanyang KongRylan J Lundgren
Jan 28, 2021·Journal of Medicinal Chemistry·Nerella Sridhar GoudPardeep Kumar
Apr 14, 2021·ChemMedChem·Davide CirilloHans-René Bjørsvik

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