Recent progress in biobutanol tolerance in microbial systems with an emphasis on Clostridium

FEMS Microbiology Letters
George L Peabody, Katy C Kao

Abstract

Biobased production of butanol promises a more sustainable route for industrial production. However, butanol toxicity remains a barrier for achieving high product titers. Investigation into butanol stress has shed some light on its modes of toxicity. Unfortunately, there still remain significant shortfalls in our understanding of the complex interactions of butanol with cells. To address this knowledge gap, a diverse range of tools have been employed to gain a better understanding of the adverse effects of butanol on the cell. These findings have lead to the identification of possible molecular mechanisms associated with butanol tolerance, which can be harnessed for future strain development efforts. This review focuses on recent efforts to address the toxicity of butanol in microbial producers and offers some perspectives on the future direction of this research sector.

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Citations

Mar 30, 2016·FEMS Microbiology Letters·Chen LiaoTing Lu
May 21, 2016·FEMS Microbiology Letters·Michael Sauer
Jan 20, 2019·Applied and Environmental Microbiology·Zhiqiang WenSheng Yang
May 30, 2019·Applied Microbiology and Biotechnology·Chi ChengShang-Tian Yang
Aug 10, 2020·Biotechnology and Bioengineering·Christopher T StraubRobert M Kelly
Aug 4, 2016·PloS One·Edward A Buehler, Ali Mesbah

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