Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.

European Journal of Medicinal Chemistry
Yi MouZheng-Yu Jiang

Abstract

Therapeutic targeting the protein-protein interaction (PPI) of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its main regulator, Kelch-like ECH-Associating protein 1 (Keap1) has been emerged as a feasible way to combat oxidative stress related diseases, due to the key role of Nrf2 in oxidative stress regulation. In recent years, many efforts have been made to develop potent Keap1-Nrf2 inhibitors with new chemical structures. Various molecules with diverse chemical structures have been reported and some compounds exhibit high potency. This review summarizes peptide and small molecule Keap1-Nrf2 inhibitors reported recently. We also highlight the pharmacological effects and discuss the possible therapeutic application of Keap1-Nrf2 inhibitors.

Citations

Jan 27, 2021·Food & Function·Zhaohui XueXiaohong Kou
Dec 10, 2020·Antioxidants·Mahdie RahbanAli A Moosavi-Movahedi
May 16, 2021·Communications Biology·Yuta HorieMasayuki Yamamoto
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Yue HaoXianhong Gu

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