Recent progress in lysosomal alpha-mannosidase and its deficiency

Experimental & Molecular Medicine
H Sun, J H Wolfe

Abstract

Lysosomal alpha-mannosidase (EC 3.2.1.24) is a major exoglycosidase in the glycoprotein degradation pathway. A deficiency of this enzyme causes the lysosomal storage disease, alpha-mannosidosis, which has been described in humans, cattle, domestic cats and guinea pigs. Recently, great progress has been made in studying the enzyme and its deficiency. This includes cloning of the gene encoding the enzyme, characterization of mutations related to the disease, establishment of valuable animal models, and encouraging results from bone marrow transplantation experiments.

Citations

Oct 10, 2007·Acta Neuropathologica·Julian A CastanedaDavid A Pearce
May 24, 2013·Journal of Inherited Metabolic Disease·Mark WalterfangDennis Velakoulis
Aug 24, 2005·The Journal of Biological Chemistry·Chaeho ParkKelley W Moremen
Sep 12, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sea Young YoonJohn H Wolfe
Dec 17, 2015·Journal of Neuropathology and Experimental Neurology·Manoj KumarHarish Poptani
Feb 26, 2005·Annals of Neurology·Charles H ViteJohn H Wolfe
Aug 6, 2003·Bone Marrow Transplantation·M H AlbertI Schmid
Nov 6, 2007·Developmental Medicine and Child Neurology·Michael J LyonsKenton R Holden
Sep 15, 2007·Neuropathology and Applied Neurobiology·D Auclair, J J Hopwood
Jan 10, 2003·Journal of Personality and Social Psychology·Henk Aarts, Ap Dijksterhuis
Jan 10, 2003·Journal of Personality and Social Psychology·Gráinne M Fitzsimons, John A Bargh
Sep 16, 2005·Journal of Personality and Social Psychology·Ruud Custers, Henk Aarts
Nov 3, 2005·Psychological Review·Ezequiel Morsella
Dec 15, 2005·Journal of Personality and Social Psychology·Kenneth G DeMarreeRichard E Petty
Jun 2, 2006·Journal of Personality and Social Psychology·Kai J Jonas, Kai Sassenberg
Mar 16, 2013·Nature Reviews. Drug Discovery·Guillaume VaquerBruno Sepodes
Jun 25, 2013·The Behavioral and Brain Sciences·Martin J Pickering, Simon Garrod
Aug 8, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·I NemčovičováJ Mucha
Dec 20, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Xiaoyun WuYang Ai
Jun 9, 2018·The Protein Journal·Aravindakshan Ajith Kumar, Nadimpalli Siva Kumar
May 19, 2019·Andrology·L HermoJ J M Bergeron
Jul 28, 2019·International Journal of Biological Macromolecules·Kavyashree Sakharayapatna RanganathaSiva Kumar Nadimpalli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.